SARS-CoV-2 RNA and antibody detection in breast milk from a prospective multicentre study in Spain
Bauerl, C.. ; Randazzo, W. ; Sánchez, G. ; Selma-Royo, M. ; García Verdevio, E. ; Martínez, L. ; Parra-Llorca, A. ; Lerín, C. ; Fumadó, V. ; Crovetto, F. ; Crispi, F. ; Pérez-Cano, F. J. ; Rodríguez, G. (Universidad de Zaragoza) ; Ruiz-Redondo, G. ; Campoy, C. ; Martínez-Costa, C. ; Collado, M. C. on behalf of MilkCORONA study team
Resumen: Objectives: To develop and validate a specific protocol for SARS-CoV-2 detection in breast milk matrix and to determine the impact of maternal SARS-CoV-2 infection on the presence, concentration and persistence of specific SARS-CoV-2 antibodies. Design and patients: This is a prospective, multicentre longitudinal study (April–December 2020) in 60 mothers with SARS-CoV-2 infection and/or who have recovered from COVID-19. A control group of 13 women before the pandemic were also included. Setting: Seven health centres from different provinces in Spain. Main outcome measures: Presence of SARS-CoV-2 RNA in breast milk, targeting the N1 region of the nucleocapsid gene and the envelope (E) gene; presence and levels of SARS-CoV-2-specific immunoglobulins (Igs)—IgA, IgG and IgM—in breast milk samples from patients with COVID-19. Results: All breast milk samples showed negative results for presence of SARS-CoV-2 RNA. We observed high intraindividual and interindividual variability in the antibody response to the receptor-binding domain of the SARS-CoV-2 spike protein for each of the three isotypes IgA, IgM and IgG. Main Protease (MPro) domain antibodies were also detected in milk. 82.9% (58 of 70) of milk samples were positive for at least one of the three antibody isotypes, with 52.9% of these positive for all three Igs. Positivity rate for IgA was relatively stable over time (65.2%–87.5%), whereas it raised continuously for IgG (from 47.8% for the first 10 days to 87.5% from day 41 up to day 206 post-PCR confirmation). Conclusions: Our study confirms the safety of breast feeding and highlights the relevance of virus-specific SARS-CoV-2 antibody transfer. This study provides crucial data to support official breastfeeding recommendations based on scientific evidence.
Idioma: Inglés
DOI: 10.1136/archdischild-2021-322463
Año: 2022
Publicado en: Archives of Disease in Childhood-Fetal and Neonatal Edition 107, 2 (2022), 217-221
ISSN: 1359-2998
Factor impacto JCR: 4.4 (2022)
Categ. JCR: PEDIATRICS rank: 13 / 130 = 0.1 (2022) - Q1 - T1
Factor impacto CITESCORE: 9.8 - Medicine (Q1)
Factor impacto SCIMAGO: 1.861 - Medicine (miscellaneous) (Q1) - Pediatrics, Perinatology and Child Health (Q1) - Obstetrics and Gynecology (Q1)
Tipo y forma: Article (Published version)
Área (Departamento): Área Pediatría (Dpto. Microb.Ped.Radio.Sal.Pú.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
Exportado de SIDERAL (2024-03-18-12:34:42)
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Idioma: Inglés
DOI: 10.1136/archdischild-2021-322463
Año: 2022
Publicado en: Archives of Disease in Childhood-Fetal and Neonatal Edition 107, 2 (2022), 217-221
ISSN: 1359-2998
Factor impacto JCR: 4.4 (2022)
Categ. JCR: PEDIATRICS rank: 13 / 130 = 0.1 (2022) - Q1 - T1
Factor impacto CITESCORE: 9.8 - Medicine (Q1)
Factor impacto SCIMAGO: 1.861 - Medicine (miscellaneous) (Q1) - Pediatrics, Perinatology and Child Health (Q1) - Obstetrics and Gynecology (Q1)
Tipo y forma: Article (Published version)
Área (Departamento): Área Pediatría (Dpto. Microb.Ped.Radio.Sal.Pú.)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2024-03-18-12:34:42)
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Record created 2022-02-08, last modified 2024-03-19