Interplay of physical activity and genetic variants of the endothelial lipase on cardiovascular disease risk factors

Salazar-Tortosa, D. F. ; Pascual-Gamarra, J. M. ; Labayen, I. ; Rupérez, A. I. ; Censi, L. ; Beghin, L. ; Michels, N. ; González-Gross, M. ; Manios, Y. ; Lambrinou, C. P. ; Moreno, L. A. (Universidad de Zaragoza) ; Meirhaeghe, A. ; Castillo, M. J. ; Ruiz, J. R.

Resumen: Background: The aim of this study was to investigate the association of endothelial lipase gene (LIPG) polymorphisms with cardiovascular disease (CVD) risk factors in adolescents and their interaction with physical activity. Methods Six polymorphisms of LIPG were genotyped in 1057 European adolescents (12-18 years old) enrolled in the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) Study. CVD risk factors related to lipid profile, blood pressure, adiposity and glucose regulation were recorded. Physical activity was objectively measured by accelerometry. Results: The major C allele of rs2000813, the minor T allele of rs2276269 and the minor G allele of rs9951026 were associated with lower levels of several CVD risk factors related to lipid profile. We also found a significant association of the TTACA LIPG haplotype (rs2000812, rs2000813, rs8093249, rs2276269 and rs9951026) with higher concentrations of low-density cholesterol and apolipoprotein B. Finally, the interaction between physical activity and the polymorphisms rs2000813, rs2276269 and rs9951026 had a significant influence on several CVD risk factors. Conclusions: LIPG polymorphisms were significantly associated with CVD risk factors in European adolescents. Interestingly, alleles of these polymorphisms were associated with a better cardiovascular profile in physically active adolescents only. High physical activity may reduce the development of CVD, modulating its genetic risk. Impact: Using gene-phenotype and gene x environment analyses, we detected associations between the endothelial lipase gene and cardiovascular risk factors, along with interactions with physical activity. This study shows that physical activity may modulate the influence of gene on cardiovascular risk in adolescents. These results bring insights into the mechanisms by which physical activity positively influences CVD in adolescents.

Idioma: Inglés

DOI: 10.1038/s41390-021-01519-1

Año: 2022

Publicado en: Pediatric research 91 (2022), 929–936
ISSN: 0031-3998

Factor impacto JCR: 3.6 (2022)

Categ. JCR: PEDIATRICS rank: 23 / 130 = 0.177 (2022) - Q1 - T1

Factor impacto CITESCORE: 6.1 - Medicine (Q1)

Factor impacto SCIMAGO: 1.04 - Pediatrics, Perinatology and Child Health (Q1)

Financiación: info:eu-repo/grantAgreement/EUR/FP6/FOOD-CT-2005-007034
Financiación: info:eu-repo/grantAgreement/ES/MEC/FPU13-03410
Financiación: info:eu-repo/grantAgreement/ES/MEC/FPU16-02127

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)