Photodynamic Therapy Combined with Antibiotics or Antifungals against Microorganisms That Cause Skin and Soft Tissue Infections: A Planktonic and Biofilm Approach to Overcome Resistances

Perez-Laguna, V ; Garcia-Luque, I ; Ballesta, S ; Rezusta López, A (Universidad de Zaragoza) ; Gilaberte Calzada, Y (Universidad de Zaragoza)

Resumen: The present review covers combination approaches of antimicrobial photodynamic therapy (aPDT) plus antibiotics or antifungals to attack bacteria and fungi in vitro (both planktonic and biofilm forms) focused on those microorganisms that cause infections in skin and soft tissues. The combination can prevent failure in the fight against these microorganisms: antimicrobial drugs can increase the susceptibility of microorganisms to aPDT and prevent the possibility of regrowth of those that were not inactivated during the irradiation; meanwhile, aPDT is effective regardless of the resistance pattern of the strain and their use does not contribute to the selection of antimicrobial resistance. Additive or synergistic antimicrobial effects in vitro are evaluated and the best combinations are presented. The use of combined treatment of aPDT with antimicrobials could help overcome the difficulty of fighting high level of resistance microorganisms and, as it is a multi-target approach, it could make the selection of resistant microorganisms more difficult.

Idioma: Inglés

DOI: 10.3390/ph14070603

Año: 2021

Publicado en: Pharmaceuticals 14, 7 (2021), 603 [21 pp]
ISSN: 1424-8247

Factor impacto JCR: 5.215 (2021)

Categ. JCR: PHARMACOLOGY & PHARMACY rank: 69 / 279 = 0.247 (2021) - Q1 - T1
Categ. JCR: CHEMISTRY, MEDICINAL rank: 16 / 63 = 0.254 (2021) - Q2 - T1

Factor impacto CITESCORE: 4.0 - Pharmacology, Toxicology and Pharmaceutics (Q2) - Biochemistry, Genetics and Molecular Biology (Q3)

Factor impacto SCIMAGO: 0.851 - Pharmaceutical Science (Q1) - Drug Discovery (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/B10-17R
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-REIPI/RD16-0016-0001

Tipo y forma: Article (Published version)

Área (Departamento): Área Microbiología (Dpto. Microb.Ped.Radio.Sal.Pú.)
Área (Departamento): Área Dermatología (Dpto. Medicina, Psiqu. y Derm.)