BXD recombinant inbred mice as a model to study neurotoxicity

Martins, A.C. ; López-Granero, C. (Universidad de Zaragoza) ; Ferrer, B. ; Tinkov, A.A. ; Skalny, A.V. ; Paoliello, M.M.B. ; Aschner, M.

Resumen: BXD recombinant inbred (RI) lines represent a genetic reference population derived from a cross between C57BL/6J mice (B6) and DBA/2J mice (D2), which through meiotic recombination events possesses recombinant chromosomes containing B6 or D2 haplotype segments. The quantitative trait loci (QTLs) are the locations of segregating genetic polymorphisms and are fundamental to understanding genetic diversity in human disease susceptibility and severity. QTL mapping represents the typical approach for identifying naturally occurring polymorphisms that influence complex phenotypes. In this process, genotypic values at markers of known genomic locations are associated with phenotypic values measured in a segregating population. Indeed, BXD RI strains provide a powerful tool to study neurotoxicity induced by different substances. In this review, we describe the use of BXD RI lines to understand the underlying mechanisms of neurotoxicity in response to ethanol and cocaine, as well as metals and pesticide exposures. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Idioma: Inglés

DOI: 10.3390/biom11121762

Año: 2021

Publicado en: Biomolecules 11, 12 (2021), 1762 [12 pp]
ISSN: 2218-273X

Factor impacto JCR: 6.064 (2021)

Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 75 / 297 = 0.253 (2021) - Q2 - T1

Factor impacto CITESCORE: 5.7 - Biochemistry, Genetics and Molecular Biology (Q2)

Factor impacto SCIMAGO: 1.019 - Molecular Biology (Q2) - Biochemistry (Q2)

Tipo y forma: Article (Published version)

Área (Departamento): Área Psicología Básica (Dpto. Psicología y Sociología)