000110614 001__ 110614
000110614 005__ 20230519145620.0
000110614 0247_ $$2doi$$a10.1038/s41416-021-01492-w
000110614 0248_ $$2sideral$$a127558
000110614 037__ $$aART-2021-127558
000110614 041__ $$aeng
000110614 100__ $$aDonat-Vargas C.
000110614 245__ $$aTrajectories of alcohol consumption during life and the risk of developing breast cancer
000110614 260__ $$c2021
000110614 5060_ $$aAccess copy available to the general public$$fUnrestricted
000110614 5203_ $$aBackground: Whether there are lifetime points of greater sensitivity to the deleterious effects of alcohol intake on the breasts remains inconclusive. Objective: To compare the influence of distinctive trajectories of alcohol consumption throughout a woman’s life on development of breast cancer (BC). Methods: 1278 confirmed invasive BC cases and matched (by age and residence) controls from the Epi-GEICAM study (Spain) were used. The novel group-based trajectory modelling was used to identify different alcohol consumption trajectories throughout women’s lifetime. Results: Four alcohol trajectories were identified. The first comprised women (45%) with low alcohol consumption (<5 g/day) throughout their life. The second included those (33%) who gradually moved from a low alcohol consumption in adolescence to a moderate in adulthood (5 to <15 g/day), never having a high consumption; and oppositely, women in the third trajectory (16%) moved from moderate consumption in adolescence, to a lower consumption in adulthood. Women in the fourth (6%) moved from a moderate alcohol consumption in adolescence to the highest consumption in adulthood (=15 g/day), never having a low alcohol consumption. Comparing with the first trajectory, the fourth doubled BC risk (OR 2.19; 95% CI 1.27, 3.77), followed by the third (OR 1.44; 0.96, 2.16) and ultimately by the second trajectory (OR 1.17; 0.86, 1.58). The magnitude of BC risk was greater in postmenopausal women, especially in those with underweight or normal weight. When alcohol consumption was independently examined at each life stage, =15 g/day of alcohol consumption in adolescence was strongly associated with BC risk followed by consumption in adulthood. Conclusions: The greater the alcohol consumption accumulated throughout life, the greater the risk of BC, especially in postmenopausal women. Alcohol consumption during adolescence may particularly influence BC risk. © 2021, The Author(s).
000110614 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000110614 590__ $$a9.082$$b2021
000110614 592__ $$a2.272$$b2021
000110614 594__ $$a12.4$$b2021
000110614 591__ $$aONCOLOGY$$b37 / 245 = 0.151$$c2021$$dQ1$$eT1
000110614 593__ $$aOncology$$c2021$$dQ1
000110614 593__ $$aCancer Research$$c2021$$dQ1
000110614 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000110614 700__ $$aGuerrero-Zotano Á.
000110614 700__ $$aCasas A.
000110614 700__ $$aBaena-Cañada J.M.
000110614 700__ $$aLope V.
000110614 700__ $$aAntolín S.
000110614 700__ $$aGarcia-Saénz J.Á.
000110614 700__ $$aBermejo B.
000110614 700__ $$aMuñoz M.
000110614 700__ $$aRamos M.
000110614 700__ $$ade Juan A.
000110614 700__ $$aJara Sánchez C.
000110614 700__ $$aSánchez-Rovira P.
000110614 700__ $$0(orcid)0000-0002-9159-4988$$aAntón Torres, A.$$uUniversidad de Zaragoza
000110614 700__ $$aBrunet J.
000110614 700__ $$aGavilá J.
000110614 700__ $$aSalvador J.
000110614 700__ $$aArriola Arellano E.
000110614 700__ $$aBezares S.
000110614 700__ $$aFernández de Larrea-Baz N.
000110614 700__ $$aPérez-Gómez B.
000110614 700__ $$aMartín M.
000110614 700__ $$aPollán M.
000110614 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000110614 773__ $$g125, 8 (2021), 1168-1176$$pBr. J. Cancer$$tBRITISH JOURNAL OF CANCER$$x0007-0920
000110614 8564_ $$s602335$$uhttps://zaguan.unizar.es/record/110614/files/texto_completo.pdf$$yVersión publicada
000110614 8564_ $$s2663432$$uhttps://zaguan.unizar.es/record/110614/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000110614 909CO $$ooai:zaguan.unizar.es:110614$$particulos$$pdriver
000110614 951__ $$a2023-05-18-16:14:16
000110614 980__ $$aARTICLE