Therapeutic molecules for osteoarthritis treatment. role of phloretin, ipriflavone and raloxifene in lipopolysaccharide induced osteoarthritic chondrocytes

Paesa, M. ; Remirez de Ganuza, C. ; Bertol, J. ; García-Alvarez, F. (Universidad de Zaragoza) ; Rodriguez Yoldi, M. (Universidad de Zaragoza) ; Irusta, S. (Universidad de Zaragoza) ; Arruebo, M. (Universidad de Zaragoza) ; Mendoza, G.

Resumen: Purpose: The search of novel molecules for the treatment of osteoarthritis (OA) is complex as any new therapeutic approach should encompass these requirements: inhibition of cartilage degradation, protection of bone and inhibition of inflammation. In the last years, different drugs have been proposed though most of them did not succeed in fulfil these requirements. Moreover, few of them have been encapsulated in drug delivery systems to improve their therapeutic potential to achieve a sustained or controlled release compared to the administration of equivalent doses of the free compounds. Nanoscience has arisen in the last decades as a potential field of study in drug delivery because nanomaterials may overcome the main current limitations to achieve an efficient and localized drug delivery by improving the targeted delivery and providing a sustained or controlled delivery to prolong the therapeutic effect. On the other hand, different polyphenols and aromatic organic compounds are known to possess anti-inflammatory, antioxidant and bone density-building properties...

Idioma: Inglés

DOI: 10.1016/j.joca.2021.05.055

Año: 2021

Publicado en: OSTEOARTHRITIS AND CARTILAGE 29, SUPP 2 (2021), S33-S35
ISSN: 1063-4584

Factor impacto JCR: 7.507 (2021)

Categ. JCR: RHEUMATOLOGY rank: 5 / 34 = 0.147 (2021) - Q1 - T1
Categ. JCR: ORTHOPEDICS rank: 2 / 86 = 0.023 (2021) - Q1 - T1

Factor impacto CITESCORE: 10.2 - Medicine (Q1) - Engineering (Q1)

Factor impacto SCIMAGO: 1.823 - Orthopedics and Sports Medicine (Q1) - Biomedical Engineering (Q1)

Tipo y forma: Congress (Published version)

Área (Departamento): Área Fisiología (Dpto. Farmac.Fisiol.y Med.L.F.)
Área (Departamento): Área Traumatología y Ortopedia (Dpto. Cirugía)
Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)
Área (Departamento): Área Tecnologi. Medio Ambiente (Dpto. Ing.Quím.Tecnol.Med.Amb.)