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> Analysis of Mycobacterium africanum in the last 17 years in Aragon identifies a specific location of IS6110 in Lineage 6
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Analysis of Mycobacterium africanum in the last 17 years in Aragon identifies a specific location of IS6110 in Lineage 6
Comín, J.
;
Monforte, M.L.
;
Samper, S.
;
Iglesias, M.J.
(Universidad de Zaragoza)
;
Ibarz, D.
(Universidad de Zaragoza)
;
Viñuelas, J.
;
Torres, L.
;
Sahagún, J.
;
Lafoz, M.C.
;
Malo, M.C.
;
Otal, I.
(Universidad de Zaragoza)
;
Aragonese Working Group on Molecular Epidemiology of Tuberculosis (EPIMOLA)
Resumen:
The purpose of this study was to increase our knowledge about Mycobacterium africanum and report the incidence and characteristics of tuberculosis (TB) due to their lineages in Aragon, Spain, over the period 2003–2019. The study includes all the cases in our region, where all the M. tuberculosis complex isolates are systematically characterised. We detected 31 cases of M. africanum among 2598 cases of TB in the period studied. TB caused by M. africanum is rare (1.19%) in our population, and it affects mainly men of economically productive age coming from West African countries. Among the isolates, Lineage (L) 6 was more frequent than L5. The genotyping of these strains identified five clusters and 13 strains with a unique pattern. The isolates’ characterisation identified a copy of IS6110 within the moaX gene, which turned out to be specific for L6. It will allow the differentiation of this lineage from the rest of MTBC with a simple PCR reaction. It remains to be established whether this polymorphism may limit M. africanum transmission. Furthermore, a mutation in the mutT2 promoter was found as specific for L6 strains, which could be related to the high variability found for L6 compared to L5. © 2021, The Author(s).
Idioma:
Inglés
DOI:
10.1038/s41598-021-89511-x
Año:
2021
Publicado en:
Scientific reports (Nature Publishing Group)
11, 1 (2021), 10359 [10 pp]
ISSN:
2045-2322
Factor impacto JCR:
4.997 (2021)
Categ. JCR:
MULTIDISCIPLINARY SCIENCES
rank: 19 / 74 = 0.257
(2021)
- Q2
- T1
Factor impacto SCIMAGO:
1.005 -
Multidisciplinary
(Q1)
Financiación:
info:eu-repo/grantAgreement/ES/ISCIII/FIS18-0336
Tipo y forma:
Article (Published version)
Área (Departamento):
Área Microbiología
(
Dpto. Microb.Ped.Radio.Sal.Pú.
)
Área (Departamento):
Área Medic.Prevent.Salud Públ.
(
Dpto. Microb.Ped.Radio.Sal.Pú.
)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
Exportado de SIDERAL (2023-05-18-15:59:40)
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Record created 2022-02-15, last modified 2023-05-19
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