A new airway spiral stent designed to maintain airway architecture with an atraumatic removal after full epithelization - Research of feasibility and viability in canine patients with tracheomalacia

Serrano-Casorran, Carolina (Universidad de Zaragoza) ; Lopez-Minguez, Sandra (Universidad de Zaragoza) ; Rodriguez-Zapater, Sergio (Universidad de Zaragoza) ; Bonastre, Cristina (Universidad de Zaragoza) ; Guirola, Jose A. (Universidad de Zaragoza) ; Gregorio Ariza, Miguel Ángel de (Universidad de Zaragoza)

Resumen: Objective: Surgical management of tracheomalacia is a challenge, with current treatments still presenting numerous complications. In the field of veterinary medicine, this same pathology is present in a significant number of dogs. For this reason, we present an experimental clinical trial performed on canines with tracheobronchomalacia, using a new atraumatic removable tracheal spiral stent (SS). Both implantation procedure and clinical improvement have been analyzed in this study.Methods: In this study, four small dogs, a mean weight of 4.89 kg and body condition scores IV‐V, were included. SS was implanted by two different surgical approaches. Image and clinical follow‐up have been performed during 90 days. Symptoms were evaluated from 1 to 10 every week. Results:
This study achieved 100% technical and clinical success. Median tracheal diameters were as follows: cervical 10.85 (3.3), inlet 7.75 (2.1), and carina 7.75 (1.9) mm, and length was 77.5 (26) mm. A 12 × 10 × 100‐mm SS was implanted in all cases. Goose honk cough punctuation improved from 8 to 1; also, there were important changes in exercise intolerance, a mean weight loss of 8.76%. The values of modified Karnofsky scale varied from 50 (20) before surgery to 90 (10) after 30 days of surgery. Neither granuloma tissue nor fractures of the prosthesis was observed.Conclusion: The results in dogs are promising, and a new therapeutic alternative seems to be available for veterinarian field. The similarity of this disease between dogs and newborns suggests that this SS design can also be useful for human trials.

Idioma: Inglés

DOI: 10.1002/ppul.24816

Año: 2020

Publicado en: PEDIATRIC PULMONOLOGY 55, 7 (2020), 1757-1764
ISSN: 8755-6863

Factor impacto JCR: 3.039 (2020)

Categ. JCR: PEDIATRICS rank: 36 / 129 = 0.279 (2020) - Q2 - T1
Categ. JCR: RESPIRATORY SYSTEM rank: 36 / 64 = 0.562 (2020) - Q3 - T2

Factor impacto SCIMAGO: 0.865 - Pulmonary and Respiratory Medicine (Q1) - Pediatrics, Perinatology and Child Health (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/B36-17R

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Radiol. y Medicina Física (Dpto. Microb.Ped.Radio.Sal.Pú.)
Área (Departamento): Área Sanidad Animal (Dpto. Patología Animal)
Área (Departamento): Área Medicina y Cirugía Animal (Dpto. Patología Animal)