Differences in trajectories and predictive factors of cognition over time in a sample of cognitively healthy adults, in zaragoza, spain

Lobo, E. (Universidad de Zaragoza) ; Gracia-García, P. (Universidad de Zaragoza) ; Lobo, A. (Universidad de Zaragoza) ; Saz, P. (Universidad de Zaragoza) ; de-la-Cámara, C. (Universidad de Zaragoza)

Resumen: Great inter-individual variability has been reported in the maintenance of cognitive function in aging. We examined this heterogeneity by modeling cognitive trajectories in a population-based longitudinal study of adults aged 55+ years. We hypothesized that (1) distinct classes of cognitive trajectories would be found, and (2) between-class differences in associated factors would be ob-served. The sample comprised 2403 cognitively healthy individuals from the Zaragoza Dementia and Depression (ZARADEMP) project, who had at least three measurements of the Mini-Mental State Examination (MMSE) in a 12-year follow-up. Longitudinal changes in cognitive functioning were modeled using growth mixture models (GMM) in the data. The best-fitting age-adjusted model showed 3 distinct trajectories, with 1-high-to-moderate (21.2% of participants), 2-moderate-stable (67.5%) and, 3-low-and-declining (9.9%) cognitive function over time, respectively. Compared with the reference 2-trajectory, the association of education and depression was significantly different in trajectories 1 and 3. Instrumental activities of daily living (iADLs) were only associated with the declining trajectory. This suggests that intervention strategies should be tailored specifically to individuals with different trajectories of cognitive aging, and intervention strategies designed to maintain cognitive function might be different from those to prevent decline. A stable cognitive performance (‘successful cognitive aging’) rather than a mild decline, might be more ‘normal’ than generally expected.

Idioma: Inglés

DOI: 10.3390/ijerph18137092

Año: 2021

Publicado en: International journal of environmental research and public health 18, 13 (2021), 18137092 [13 pp.]
ISSN: 1661-7827

Factor impacto JCR: 4.614 (2021)

Categ. JCR: PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH rank: 45 / 183 = 0.246 (2021) - Q1 - T1
Categ. JCR: PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH rank: 71 / 210 = 0.338 (2021) - Q2 - T2
Categ. JCR: ENVIRONMENTAL SCIENCES rank: 100 / 279 = 0.358 (2021) - Q2 - T2

Factor impacto CITESCORE: 4.5 - Medicine (Q2) - Environmental Science (Q2)

Factor impacto SCIMAGO: 0.814 - Pollution (Q1) - Health, Toxicology and Mutagenesis (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/B15-17R
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI-19-01874
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/01-0255
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/03-0815
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/06-0617
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/94-1562
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/97-1321E
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/98-0103
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI19-00948
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/12-02254
Financiación: info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/16-00896

Tipo y forma: Article (Published version)

Área (Departamento): Area Anatom.Embriol.Humana (Dpto. Anatom.Histolog.Humanas)
Área (Departamento): Area Psiquiatría (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Medic.Prevent.Salud Públ. (Dpto. Microb.Ped.Radio.Sal.Pú.)