Multiparametric Magnetic Resonance Imaging Grades the Aggressiveness of Prostate Cancer

Morote, Juan ; Borque-Fernando, Angel (Universidad de Zaragoza) ; Triquell, Marina ; Celma, Anna ; Regis, Lucas ; Mast, Richard ; de Torres, Inés M. ; Semidey, María E. ; Santamaría, Anna ; Planas, Jacques ; Esteban, Luis M. ; Trilla, Enrique

Resumen: We sought to find further evidence showing the increase in PCa aggressiveness as PI-RADS score increases from four surrogates of PCa aggressiveness: i. prostate biopsy GG (≤3 vs. >3), ii. type of pathology in surgical specimens (favourable vs. unfavourable), iii. clinical stage (localised vs. advanced), and risk of recurrence of localised PCa after primary treatment (low-intermediate vs. high). A group of 692 PCa patients were diagnosed after 3-T multiparametric MRI (mpMRI) and guided and/or systematic biopsies, showing csPCa (GG ≥ 2) in 547 patients (79%) and insignificant PCa (iPCa) in 145 (21%). The csPCa rate increased from 32.4% in PI-RADS < 3 to 95.5% in PI-RADS 5 (p < 0.001). GG ≥ 3 was observed in 7.6% of PCa with PI-RADS < 3 and 32.6% in those with PI-RADS > 3 (p < 0.001). Unfavourable pathology was observed in 38.9% of PCa with PI-RAD < 3 and 68.3% in those with PI-RADS > 3 (p = 0.030). Advanced disease was not observed in PCa with PI-RADS ≤ 3, while it existed in 12.7% of those with PI-RADS > 3 (p < 0.001). High-risk recurrence localised PCa was observed in 9.5% of PCa with PI-RADS < 3 and 35% in those with PI-RADS > 3 (p = 0.001). The PI-RADS score was an independent predictor of all surrogates of PCa aggressiveness as PSA density. We confirmed that mpMRI grades PCa aggressiveness.

Idioma: Inglés

DOI: 10.3390/cancers14071828

Año: 2022

Publicado en: Cancers 14, 7 (2022), 1828 [9 p.]
ISSN: 2072-6694

Factor impacto JCR: 5.2 (2022)

Categ. JCR: ONCOLOGY rank: 72 / 241 = 0.299 (2022) - Q2 - T1

Factor impacto CITESCORE: 7.4 - Medicine (Q1) - Biochemistry, Genetics and Molecular Biology (Q2)

Factor impacto SCIMAGO: 1.312 - Oncology (Q1) - Cancer Research (Q2)

Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI20/01666

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Urología (Dpto. Cirugía)