SR-B1, a Key Receptor Involved in the Progression of Cardiovascular Disease: A Perspective from Mice and Human Genetic Studies

Gracia Rubio, Irene ; Martín, C. ; Civeira, Fernando (Universidad de Zaragoza) ; Cenarro, Ana

Resumen: High plasma level of low-density lipoprotein (LDL) is the main driver of the initiation and progression of cardiovascular disease (CVD). Nevertheless, high-density lipoprotein (HDL) is con-sidered an anti-atherogenic lipoprotein due to its role in reverse cholesterol transport and its ability to receive cholesterol that effluxes from macrophages in the artery wall. The scavenger receptor B class type 1 (SR-B1) was identified as the high-affinity HDL receptor, which facilitates the selective uptake of cholesterol ester (CE) into the liver via HDL and is also implicated in the plasma clearance of LDL, very low-density lipoprotein (VLDL) and lipoprotein(a) (Lp(a)). Thus, SR-B1 is a multifunc-tional receptor that plays a main role in the metabolism of different lipoproteins. The aim of this review is to highlight the association between SR-B1 and CVD risk through mice and human genetic studies.

Idioma: Inglés

DOI: 10.3390/biomedicines9060612

Año: 2021

Publicado en: Biomedicines 9, 6 (2021), 612 [18 pp.]
ISSN: 2227-9059

Factor impacto JCR: 4.757 (2021)

Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 121 / 297 = 0.407 (2021) - Q2 - T2
Categ. JCR: PHARMACOLOGY & PHARMACY rank: 87 / 279 = 0.312 (2021) - Q2 - T1
Categ. JCR: MEDICINE, RESEARCH & EXPERIMENTAL rank: 62 / 139 = 0.446 (2021) - Q2 - T2

Factor impacto CITESCORE: 3.0 - Medicine (Q2) - Biochemistry, Genetics and Molecular Biology (Q3)

Factor impacto SCIMAGO: 0.874 - Medicine (miscellaneous) (Q1) - Biochemistry, Genetics and Molecular Biology (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/B14-7R
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/CD19-00245
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI19-00694
Financiación: info:eu-repo/grantAgreement/ES/MICINN-ISCIII/PI18-01777

Tipo y forma: Article (Published version)

Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)