Horizons in Asymmetric Organocatalysis: En Route to the Sustainability and New Applications

Ardevines, Sandra (Universidad de Zaragoza) ; Marqués-López, Eugenia (Universidad de Zaragoza) ; Pérez Herrera, Raquel

Resumen: Nowadays, the development of new enantioselective processes is highly relevant in chemistry due to the relevance of chiral compounds in biomedicine (mainly drugs) and in other fields, such as agrochemistry, animal feed, and flavorings. Among them, organocatalytic methods have become an efficient and sustainable alternative since List and MacMillan pioneering contributions were published in 2000. These works established the term asymmetric organocatalysis to label this area of research, which has grown exponentially over the last two decades. Since then, the scientific community has attended to the discovery of a plethora of organic reactions and transformations carried out with excellent results in terms of both reactivity and enantioselectivity. Looking back to earlier times, we can find in the literature a few examples where small organic molecules and some natural products could act as effective catalysts. However, with the birth of this type of catalysis, new chemical architectures based on amines, thioureas, squaramides, cinchona alkaloids, quaternary ammonium salts, carbenes, guanidines and phosphoric acids, among many others, have been devel-oped. These organocatalysts have provided a broad range of activation modes that allow privileged interactions between catalysts and substrates for the preparation of compounds with high added value in an enantioselective way. Here, we briefly cover the history of this chemistry, from our point of view, including our beginnings, how the field has evolved during these years of research, and the road ahead. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Idioma: Inglés

DOI: 10.3390/catal12010101

Año: 2022

Publicado en: Catalysts 12, 1 (2022), [13 pp.]
ISSN: 2073-4344

Factor impacto JCR: 3.9 (2022)

Categ. JCR: CHEMISTRY, PHYSICAL rank: 71 / 161 = 0.441 (2022) - Q2 - T2

Factor impacto CITESCORE: 6.3 - Environmental Science (Q1) - Chemistry (Q2) - Chemical Engineering (Q2)

Factor impacto SCIMAGO: 0.69 - Physical and Theoretical Chemistry (Q2) - Catalysis (Q2)

Financiación: info:eu-repo/grantAgreement/ES/AEI/PID2020-117455GB-I00
Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/E07-20R

Tipo y forma: Article (Published version)

Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)