000112741 001__ 112741
000112741 005__ 20240319080951.0
000112741 0247_ $$2doi$$a10.1016/j.bbr.2021.113545
000112741 0248_ $$2sideral$$a128355
000112741 037__ $$aART-2022-128355
000112741 041__ $$aeng
000112741 100__ $$aArenas, M. Carmen
000112741 245__ $$aPrepulse inhibition can predict the motivational effects of cocaine in female mice exposed to maternal separation
000112741 260__ $$c2022
000112741 5060_ $$aAccess copy available to the general public$$fUnrestricted
000112741 5203_ $$aThe prepulse inhibition (PPI) of the startle response can identify the rodents that are more sensitive to the effects of cocaine. Mice with a lower PPI presented a higher vulnerability to the effects of cocaine and a higher susceptibility to developing a substance use disorder (SUD). Maternal separation with early weaning (MSEW) is a relevant animal model to induce motivational alterations throughout life. Nevertheless, only a few studies on females exist, even though they are more vulnerable to stress- and cocaine-related problems. Hence, the aim of the present study was to evaluate the ability of PPI to identify females with a greater vulnerability to the longterm consequences of early stress on the motivational effects of cocaine. Female mice underwent MSEW and were classified according to their high or low PPI. They were then assessed in the cocaine-induced locomotor sensitization test, the conditioned place preference paradigm or the operant self-administration paradigm. Additionally, they were also evaluated in the passive avoidance task, the tail-suspension and the splash tests. The results revealed that the females with lower PPI presented higher consequences of MSEW on the effects of cocaine and showed an increase in anhedonia-like behaviours. Our findings support that a PPI deficit could represent a biomarker of vulnerability to the effects of cocaine induced by MSEW.
000112741 536__ $$9info:eu-repo/grantAgreement/ES/FEDER/Una manera de hacer Europa$$9info:eu-repo/grantAgreement/ES/ISCIII/RD16-0017-0007$$9info:eu-repo/grantAgreement/ES/ISCIII/RD16-0017-010$$9info:eu-repo/grantAgreement/ES/MINECO/PSI2017-83023$$9info:eu-repo/grantAgreement/ES/MINECO/SAF2016-75966
000112741 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000112741 590__ $$a2.7$$b2022
000112741 592__ $$a0.881$$b2022
000112741 591__ $$aBEHAVIORAL SCIENCES$$b20 / 52 = 0.385$$c2022$$dQ2$$eT2
000112741 593__ $$aBehavioral Neuroscience$$c2022$$dQ2
000112741 591__ $$aNEUROSCIENCES$$b188 / 272 = 0.691$$c2022$$dQ3$$eT3
000112741 594__ $$a6.2$$b2022
000112741 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000112741 700__ $$aCastro-Zavala, Adriana
000112741 700__ $$aMartin-Sanchez, Ana
000112741 700__ $$0(orcid)0000-0001-5990-1266$$aBlanco-Gandia, Maria Carmen$$uUniversidad de Zaragoza
000112741 700__ $$aMinarro, Jose
000112741 700__ $$aValverde, Olga
000112741 700__ $$aManzanedo, Carmen
000112741 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac
000112741 773__ $$g416 (2022), 113545 [13 pp.]$$pBehav. brain res.$$tBehavioural brain research$$x0166-4328
000112741 8564_ $$s3890669$$uhttps://zaguan.unizar.es/record/112741/files/texto_completo.pdf$$yVersión publicada
000112741 8564_ $$s2624210$$uhttps://zaguan.unizar.es/record/112741/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000112741 909CO $$ooai:zaguan.unizar.es:112741$$particulos$$pdriver
000112741 951__ $$a2024-03-18-13:04:39
000112741 980__ $$aARTICLE