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> Pathogenicity and Its Implications in Taxonomy: The Brucella and Ochrobactrum Case
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Pathogenicity and Its Implications in Taxonomy: The Brucella and Ochrobactrum Case
Moreno, E.
;
Blasco, J. M.
;
Letesson, J. J.
;
Gorvel, J. P.
;
Moriyón, I.
Resumen:
The intracellular pathogens of the genus Brucella are phylogenetically close to Ochrobac-trum, a diverse group of free-living bacteria with a few species occasionally infecting medically compromised patients. A group of taxonomists recently included all Ochrobactrum organisms in the genus Brucella based on global genome analyses and alleged equivalences with genera such as Mycobacterium. Here, we demonstrate that such equivalencies are incorrect because they overlook the complexities of pathogenicity. By summarizing Brucella and Ochrobactrum divergences in lifestyle, structure, physiology, population, closed versus open pangenomes, genomic traits, and pathogenicity, we show that when they are adequately understood, they are highly relevant in taxonomy and not unidimensional quantitative characters. Thus, the Ochrobactrum and Brucella differences are not limited to their assignments to different “risk-groups”, a biologically (and hence, taxonomically) oversimplified description that, moreover, does not support ignoring the nomen periculosum rule, as proposed. Since the epidemiology, prophylaxis, diagnosis, and treatment are thoroughly unrelated, merging free-living Ochrobactrum organisms with highly pathogenic Brucella organisms brings evi-dent risks for veterinarians, medical doctors, and public health authorities who confront brucellosis, a significant zoonosis worldwide. Therefore, from taxonomical and practical standpoints, the Brucella and Ochrobactrum genera must be maintained apart. Consequently, we urge researchers, culture collections, and databases to keep their canonical nomenclature. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Idioma:
Inglés
DOI:
10.3390/pathogens11030377
Año:
2022
Publicado en:
Pathogens
11, 3 (2022), 377 - [18 pp]
ISSN:
2076-0817
Factor impacto JCR:
3.7 (2022)
Categ. JCR:
MICROBIOLOGY
rank: 62 / 135 = 0.459
(2022)
- Q2
- T2
Factor impacto CITESCORE:
5.1 -
Biochemistry, Genetics and Molecular Biology
(Q2) -
Immunology and Microbiology
(Q2) -
Medicine
(Q2)
Factor impacto SCIMAGO:
0.807 -
Immunology and Allergy
(Q2) -
Immunology and Microbiology (miscellaneous)
(Q2) -
Molecular Biology
(Q2) -
Microbiology (medical)
(Q2) -
Infectious Diseases
(Q2)
Financiación:
info:eu-repo/grantAgreement/ES/DGA/A13-17R
Financiación:
info:eu-repo/grantAgreement/ES/MINECO/PID2019-107601RA-C32
Tipo y forma:
Article (Published version)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
Exportado de SIDERAL (2024-03-18-13:11:11)
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Record created 2022-06-17, last modified 2024-03-19
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