Microfluidic Synthesis of Block Copolymer Micelles: Application as Drug Nanocarriers and as Photothermal Transductors When Loading Pd Nanosheets

Abad, Miriam (Universidad de Zaragoza) ; Mendoza, Gracia ; Uson, Laura ; Arruebo, Manuel (Universidad de Zaragoza) ; Piñol, Milagros (Universidad de Zaragoza) ; Sebastian, Victor (Universidad de Zaragoza) ; Oriol, Luis (Universidad de Zaragoza)

Resumen: The synthesis of polymeric nanoparticles from a block copolymer based on poly(ethylene glycol) and a polymethacrylate containing the nucleobase analog 2, 6-diacylaminopyridine is optimized by microfluidics to obtain homogeneous spherical micelles. Loading and delivery properties are studied using naproxen as a model. The incorporation of a Pd precursor in the polymer organic solution fed into the micromixer allows the preparation of Pd(II) precursor-polymer hybrid systems and the subsequent reduction with CO leads to the in situ synthesis of Pd nanosheets inside of the hydrophobic core of the polymeric micelles. This methodology is highly efficient to yield all polymeric nanoparticles loaded with Pd nanosheets as detected by electron microscopy and energy-dispersive X-ray spectroscopy. The cell viability of these Pd nanosheets-containing polymeric nanoparticles is evaluated using five cell lines, showing a high cytocompatibility at the tested concentrations without detrimental effects in cell membrane and nuclei. Furthermore, the use of these hybrid polymeric nanoparticles as photothermal transductors is evaluated using near infrared as irradiation source as well as its application in photothermal therapy using different cell lines demonstrating a high efficiency in all cell cultures.

Idioma: Inglés

DOI: 10.1002/mabi.202100528

Año: 2022

Publicado en: Macromolecular Bioscience 22, 5 (2022), 2100528 [14 pp]
ISSN: 1616-5187

Factor impacto JCR: 4.6 (2022)

Categ. JCR: POLYMER SCIENCE rank: 18 / 85 = 0.212 (2022) - Q1 - T1
Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 97 / 285 = 0.34 (2022) - Q2 - T2
Categ. JCR: MATERIALS SCIENCE, BIOMATERIALS rank: 21 / 45 = 0.467 (2022) - Q2 - T2

Factor impacto CITESCORE: 8.4 - Materials Science (Q1) - Chemical Engineering (Q1) - Biochemistry, Genetics and Molecular Biology (Q1)

Factor impacto SCIMAGO: 0.855 - Materials Chemistry (Q1) - Polymers and Plastics (Q1) - Biomaterials (Q2) - Bioengineering (Q2) - Biotechnology (Q2)

Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/E47-17R
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-IIS/MS19-00092
Financiación: info:eu-repo/grantAgreement/ES/MICINN/RTI2018-099019-A-I00
Financiación: info:eu-repo/grantAgreement/ES/MINECO/MAT2017-84838-P

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)
Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)