000117435 001__ 117435
000117435 005__ 20240319080957.0
000117435 0247_ $$2doi$$a10.1002/mabi.202100528
000117435 0248_ $$2sideral$$a128686
000117435 037__ $$aART-2022-128686
000117435 041__ $$aeng
000117435 100__ $$0(orcid)0000-0002-8677-3316$$aAbad, Miriam$$uUniversidad de Zaragoza
000117435 245__ $$aMicrofluidic Synthesis of Block Copolymer Micelles: Application as Drug Nanocarriers and as Photothermal Transductors When Loading Pd Nanosheets
000117435 260__ $$c2022
000117435 5060_ $$aAccess copy available to the general public$$fUnrestricted
000117435 5203_ $$aThe synthesis of polymeric nanoparticles from a block copolymer based on poly(ethylene glycol) and a polymethacrylate containing the nucleobase analog 2, 6-diacylaminopyridine is optimized by microfluidics to obtain homogeneous spherical micelles. Loading and delivery properties are studied using naproxen as a model. The incorporation of a Pd precursor in the polymer organic solution fed into the micromixer allows the preparation of Pd(II) precursor-polymer hybrid systems and the subsequent reduction with CO leads to the in situ synthesis of Pd nanosheets inside of the hydrophobic core of the polymeric micelles. This methodology is highly efficient to yield all polymeric nanoparticles loaded with Pd nanosheets as detected by electron microscopy and energy-dispersive X-ray spectroscopy. The cell viability of these Pd nanosheets-containing polymeric nanoparticles is evaluated using five cell lines, showing a high cytocompatibility at the tested concentrations without detrimental effects in cell membrane and nuclei. Furthermore, the use of these hybrid polymeric nanoparticles as photothermal transductors is evaluated using near infrared as irradiation source as well as its application in photothermal therapy using different cell lines demonstrating a high efficiency in all cell cultures.
000117435 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/E47-17R$$9info:eu-repo/grantAgreement/ES/ISCIII-IIS/MS19-00092$$9info:eu-repo/grantAgreement/ES/MICINN/RTI2018-099019-A-I00$$9info:eu-repo/grantAgreement/ES/MINECO/MAT2017-84838-P
000117435 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000117435 590__ $$a4.6$$b2022
000117435 592__ $$a0.855$$b2022
000117435 591__ $$aPOLYMER SCIENCE$$b18 / 85 = 0.212$$c2022$$dQ1$$eT1
000117435 593__ $$aMaterials Chemistry$$c2022$$dQ1
000117435 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b97 / 285 = 0.34$$c2022$$dQ2$$eT2
000117435 593__ $$aPolymers and Plastics$$c2022$$dQ1
000117435 591__ $$aMATERIALS SCIENCE, BIOMATERIALS$$b21 / 45 = 0.467$$c2022$$dQ2$$eT2
000117435 593__ $$aBiomaterials$$c2022$$dQ2
000117435 593__ $$aBioengineering$$c2022$$dQ2
000117435 593__ $$aBiotechnology$$c2022$$dQ2
000117435 594__ $$a8.4$$b2022
000117435 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000117435 700__ $$0(orcid)0000-0003-2293-363X$$aMendoza, Gracia
000117435 700__ $$0(orcid)0000-0002-4678-7465$$aUson, Laura
000117435 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, Manuel$$uUniversidad de Zaragoza
000117435 700__ $$0(orcid)0000-0001-5556-2172$$aPiñol, Milagros$$uUniversidad de Zaragoza
000117435 700__ $$0(orcid)0000-0002-6873-5244$$aSebastian, Victor$$uUniversidad de Zaragoza
000117435 700__ $$0(orcid)0000-0002-0922-5615$$aOriol, Luis$$uUniversidad de Zaragoza
000117435 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000117435 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000117435 773__ $$g22, 5 (2022), 2100528 [14 pp]$$pMacromol. biosci.$$tMacromolecular Bioscience$$x1616-5187
000117435 8564_ $$s5830197$$uhttps://zaguan.unizar.es/record/117435/files/texto_completo.pdf$$yVersión publicada
000117435 8564_ $$s2636295$$uhttps://zaguan.unizar.es/record/117435/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000117435 909CO $$ooai:zaguan.unizar.es:117435$$particulos$$pdriver
000117435 951__ $$a2024-03-18-13:45:39
000117435 980__ $$aARTICLE