Intrinsic and selective activity of functionalized carbon nanotube/nanocellulose platforms against colon cancer cells

González-Domínguez, J. M. ; Grasa, L. (Universidad de Zaragoza) ; Frontiñán-Rubio, J. ; Abás, E. ; Domínguez-Alfaro, A. ; Mesonero, J. E. (Universidad de Zaragoza) ; Criado, A. ; Ansón-Casaos, A.

Resumen: Given their large surface area and versatile chemical reactivity, single-walled carbon nanotubes (SWCNTs) are regarded as the basis of new pharmacological complexes. In this study, SWCNTs are chemically functionalized with fluorescein, folic acid, and capecitabine, a drug that is commonly used against colorectal cancer. These functionalized SWCNTs are dispersed in water by taking advantage of their synergistic interaction with type-II nanocrystalline cellulose (II-NCC), and the resulting colloidal system is tested in vitro on both normal (differentiated) and cancerous (proliferative) human colon cells (Caco-2). The functionalized SWCNT/II-NCC hybrids show a higher activity than the reference (capecitabine) against the Caco-2 cancer cell line. However, this effect appears to be intrinsically associated with the SWCNT/II-NCC complex, particularly boosted by fluorescein, as the presence of capecitabine is not required. In addition, confocal microscopy fluorescence imaging using cell cultures highlights the enormous potential of this nanohybrid platform for colon cancer theranostics. © 2022 The Authors

Idioma: Inglés

DOI: 10.1016/j.colsurfb.2022.112363

Año: 2022

Publicado en: COLLOIDS AND SURFACES B-BIOINTERFACES 212, 112363 (2022), [14 pp]
ISSN: 0927-7765

Factor impacto JCR: 5.8 (2022)

Categ. JCR: BIOPHYSICS rank: 9 / 70 = 0.129 (2022) - Q1 - T1
Categ. JCR: MATERIALS SCIENCE, BIOMATERIALS rank: 14 / 45 = 0.311 (2022) - Q2 - T1
Categ. JCR: CHEMISTRY, PHYSICAL rank: 51 / 161 = 0.317 (2022) - Q2 - T1

Factor impacto CITESCORE: 11.0 - Physics and Astronomy (Q1) - Biochemistry, Genetics and Molecular Biology (Q1) - Chemistry (Q1) - Chemical Engineering (Q1) - Medicine (Q1)

Factor impacto SCIMAGO: 0.868 - Physical and Theoretical Chemistry (Q1) - Colloid and Surface Chemistry (Q2) - Surfaces and Interfaces (Q2) - Biotechnology (Q2) - Medicine (miscellaneous) (Q2)

Financiación: info:eu-repo/grantAgreement/ES/DGA/A20-20R
Financiación: info:eu-repo/grantAgreement/ES/DGA/T03-17R
Financiación: info:eu-repo/grantAgreement/ES/DGA/T03-20R

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Fisiología (Dpto. Farmac.Fisiol.y Med.L.F.)