000117636 001__ 117636
000117636 005__ 20240319081011.0
000117636 0247_ $$2doi$$a10.3390/toxins14050291
000117636 0248_ $$2sideral$$a129073
000117636 037__ $$aART-2022-129073
000117636 041__ $$aeng
000117636 100__ $$aLlorens, Paula
000117636 245__ $$aBiomarkers of Exposure to Zearalenone in In Vivo and In Vitro Studies
000117636 260__ $$c2022
000117636 5060_ $$aAccess copy available to the general public$$fUnrestricted
000117636 5203_ $$aThe measurement of human exposure to mycotoxins is necessary for its association with adverse health effects. This exposure is usually estimated from contamination levels of foodstuffs, which are the primary source of toxin exposure, and data on food consumption patterns. However, variations in contamination level, intestinal absorption, toxin distribution, and excretion lead to individual variations in toxin exposure that can be more readily measured with a biomarker. This review deals with the latest literature information about ZEN biomarkers in humans, animals, and cell line cultures. Their presence in urine, biomarkers that have effects in the kidney, liver, reproductive system and blood and biomarkers of cell response have been reported. It has highlighted the importance of determining a-zearalenol and ß-zearalenol biomarkers to estimate the probable dietary intake (PDI) of a specific population or to characterize the severity of exposure to ZEN in animals or cell lines. a-ZEL and ß-ZEL are cytotoxic by inhibiting cell proliferation, total protein and DNA syntheses, in this sense, an induction of expression proteins Hsp27 and Hsp70 was observed, and an increase in gene expression (TLR4, NF-kBp65, TNF-a, IL-1ß, IL-6, IL-8, MGMT, a-GST, Hsp70, Nrf2, L-Fabp, HO-1, MAPK8), the determination of which indicates an oxidative stress effect. The integrity of the cell or tissue membrane is assessed by lactate dehydrogenase (LDH), which increase at exposure of ZEN (84.2 µM), and the proportions of some fatty acids of the renal tissue membrane were increased at treatments with ZEN. This review allows starting future studies of animal and population exposure in parallel with those of health effects works. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
000117636 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2019-PID2019-108070RB-I00ALI$$9info:eu-repo/grantAgreement/ES/DGA/A06-20R
000117636 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000117636 590__ $$a4.2$$b2022
000117636 592__ $$a0.87$$b2022
000117636 591__ $$aTOXICOLOGY$$b23 / 94 = 0.245$$c2022$$dQ1$$eT1
000117636 593__ $$aToxicology$$c2022$$dQ1
000117636 591__ $$aFOOD SCIENCE & TECHNOLOGY$$b45 / 142 = 0.317$$c2022$$dQ2$$eT1
000117636 593__ $$aHealth, Toxicology and Mutagenesis$$c2022$$dQ2
000117636 594__ $$a7.5$$b2022
000117636 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000117636 700__ $$0(orcid)0000-0002-2469-0363$$aHerrera, Marta$$uUniversidad de Zaragoza
000117636 700__ $$aJuan-García, Ana
000117636 700__ $$aPayá, Juan José
000117636 700__ $$aMoltó, Juan Carlos
000117636 700__ $$0(orcid)0000-0001-6325-7100$$aAriño, Agustín$$uUniversidad de Zaragoza
000117636 700__ $$aJuan, Cristina
000117636 7102_ $$12008$$2640$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Nutrición Bromatología
000117636 773__ $$g14, 5 (2022), 291 [16 pp.]$$pToxins$$tToxins$$x2072-6651
000117636 8564_ $$s1000945$$uhttps://zaguan.unizar.es/record/117636/files/texto_completo.pdf$$yVersión publicada
000117636 8564_ $$s2499422$$uhttps://zaguan.unizar.es/record/117636/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000117636 909CO $$ooai:zaguan.unizar.es:117636$$particulos$$pdriver
000117636 951__ $$a2024-03-18-15:11:42
000117636 980__ $$aARTICLE