Resilience to the effects of social stress on vulnerability to developing drug addiction
Calpe-Lopez, Claudia ; Martinez-Caballero, Maria A. ; Garcia-Pardo, Maria P. (Universidad de Zaragoza) ; Aguilar, Maria A.
Resumen: We review the still scarce but growing literature on resilience to the effects of social stress on the rewarding properties of drugs of abuse. We define the concept of resilience and how it is applied to the field of drug addiction research. We also describe the internal and external protective factors associated with resilience, such as individual behavioral traits and social support. We then explain the physiological response to stress and how it is modulated by resilience factors. In the subsequent section, we describe the animal models commonly used in the study of resilience to social stress, and we focus on the effects of chronic social defeat (SD), a kind of stress induced by repeated experience of defeat in an agonistic encounter, on different animal behaviors (depression- and anxiety-like behavior, cognitive impairment and addiction-like symptoms). We then summarize the current knowledge on the neurobiological substrates of resilience derived from studies of resilience to the effects of chronic SD stress on depression- and anxiety-related behaviors in rodents. Finally, we focus on the limited studies carried out to explore resilience to the effects of SD stress on the rewarding properties of drugs of abuse, describing the current state of knowledge and suggesting future research directions.
Idioma: Inglés
DOI: 10.5498/wjp.v12.i1.24
Año: 2022
Publicado en: WORLD JOURNAL OF PSYCHIATRY 12, 1 (2022), 24-58
ISSN: 2220-3206
Factor impacto JCR: 3.1 (2022)
Categ. JCR: PSYCHIATRY rank: 91 / 154 = 0.591 (2022) - Q3 - T2
Tipo y forma: Article (Published version)
Área (Departamento): Área Psicolog.Evolut.Educac (Dpto. Psicología y Sociología)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes.
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Idioma: Inglés
DOI: 10.5498/wjp.v12.i1.24
Año: 2022
Publicado en: WORLD JOURNAL OF PSYCHIATRY 12, 1 (2022), 24-58
ISSN: 2220-3206
Factor impacto JCR: 3.1 (2022)
Categ. JCR: PSYCHIATRY rank: 91 / 154 = 0.591 (2022) - Q3 - T2
Tipo y forma: Article (Published version)
Área (Departamento): Área Psicolog.Evolut.Educac (Dpto. Psicología y Sociología)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. Exportado de SIDERAL (2024-03-18-16:48:39)
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Articles > Artículos por área > Psicología Evolutiva y de la Educación
Record created 2022-07-11, last modified 2024-03-19