Evaluation of progressive visual dysfunction and retinal degeneration in patients with parkinson’s disease

Satue, M. ; Rodrigo, M.J. ; Obis, J. ; Vilades, E. ; Gracia, H. ; Otin, S. (Universidad de Zaragoza) ; Fuertes, M.I. (Universidad de Zaragoza) ; Alarcia, R. ; Crespo, J.A. ; Polo, V. (Universidad de Zaragoza) ; Larrosa, J.M. (Universidad de Zaragoza) ; Pablo, L.E. (Universidad de Zaragoza) ; Garcia-Martin, E. (Universidad de Zaragoza)

Resumen: PURPOSE. To quantify changes in visual function parameters and in the retinal nerve fiber layer and macular thickness over a 5-year period in patients with Parkinson’s disease (PD). METHODS. Thirty patients with PD and 30 healthy subjects underwent a complete ophthalmic evaluation, including assessment of visual acuity, contrast sensitivity vision, color vision, and retinal evaluation with spectral-domain optical coherence tomography (SD-OCT). All subjects were reevaluated after 5 years to quantify changes in visual function parameters, the retinal nerve fiber layer, and macular thickness. Association between progressive ophthalmologic changes and disease progression was analyzed. RESULTS. Changes were detected in visual function parameters and retinal nerve fiber layer thickness in patients compared with controls. Greater changes were found during the follow-up in the PD group than healthy subjects in visual acuity, contrast sensitivity, Lanthony color test (P < 0.016), in superotemporal and temporal retinal nerve fiber layer sectors (P < 0.001), and in macular thickness (all sectors except inner superior and inner inferior sectors, P < 0.001). Progressive changes in the retinal nerve fiber layer were associated with disease progression (r = 0.389, P = 0.028). CONCLUSIONS. Progressive visual dysfunction, macular thinning, and axonal loss can be detected in PD. Analysis of the macular thickness and the retinal nerve fiber layer by SD-OCT can be useful for evaluating Parkinson’s disease progression.

Idioma: Inglés

DOI: 10.1167/iovs.16-20460

Año: 2017

Publicado en: Investigative ophthalmology & visual science 58, 2 (2017), 1151-1157
ISSN: 0146-0404

Factor impacto JCR: 3.388 (2017)

Categ. JCR: OPHTHALMOLOGY rank: 9 / 59 = 0.153 (2017) - Q1 - T1

Factor impacto SCIMAGO: 2.058 - Cellular and Molecular Neuroscience (Q1) - Sensory Systems (Q1) - Ophthalmology (Q1)

Financiación: info:eu-repo/grantAgreement/ES/ISCIII/CM14-00026
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI14-01499

Tipo y forma: Article (Published version)

Área (Departamento): Área Oftalmología (Dpto. Cirugía,Ginecol.Obstetr.)
Área (Departamento): Área Óptica (Dpto. Física Aplicada)