The significant influence of a second metal on the antiproliferative properties of the complex [Ru(¿6-C10H14)(Cl2)(dmoPTA)]

Kordestani N. ; Abas, Elisa (Universidad de Zaragoza) ; Grasa, Laura (Universidad de Zaragoza) ; Alguacil, Andrés ; Scalambra, Franco ; Romerosa, Antonio

Resumen: Complexes [Ru(¿6-C10H14)(Cl2)(HdmoPTA)](OSO2CF3) (1), [Ru(¿6-C10H14)(Cl2)(dmoPTA)] (2) and [Ru(¿6-C10H14)(Cl2)-µ-dmoPTA-1¿P:2¿2N, N’-MCl2] (M=Zn (3), Co (4), Ni (5), dmoPTA=3, 7-dimethyl-1, 3, 7-triaza-5-phosphabicyclo[3.3.1]nonane) have been synthesized and characterized by elemental analysis and spectroscopic techniques. The crystal structures of 1, 3 and 5 were obtained by single-crystal X-ray diffraction. The antiproliferative activity of the complexes was evaluated against colon cancer cell line Caco-2/TC7 by using the MTT protocol. The monometallic ruthenium complexes 1 and 2 were found to be inactive, but the bimetallic complexes 3, 4 and 5 display an increased activity (IC50 3: 9.07±0.27, 4: 5.40±0.19, 5: 7.15±0.30 µM) compared to cisplatin (IC50=45.6±8.08 µM). Importantly, no reduction in normal cell viability was observed in the presence of the complexes. Experiments targeted to obtain information on the possible action mechanism of the complexes, such as cell cycle, ROS and gene expression studies, were performed. The results showed that the complexes display different properties and action mechanism depending on the nature of metal, M, bonded to the CH3NdmoPTA atoms. © 2021 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH

Idioma: Inglés

DOI: 10.1002/chem.202103048

Año: 2021

Publicado en: Chemistry - A European Journal 28, 3 (2021), 202103048 [12p]
ISSN: 0947-6539

Factor impacto JCR: 5.02 (2021)

Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 64 / 180 = 0.356 (2021) - Q2 - T2

Factor impacto CITESCORE: 9.1 - Chemical Engineering (Q1)

Factor impacto SCIMAGO: 1.343 - Chemistry (miscellaneous) (Q1) - Catalysis (Q1)

Tipo y forma: Article (Published version)

Área (Departamento): Área Química Analítica (Dpto. Química Analítica)
Área (Departamento): Área Fisiología (Dpto. Farmac.Fisiol.y Med.L.F.)