000118283 001__ 118283 000118283 005__ 20240319081021.0 000118283 0247_ $$2doi$$a10.1016/j.chroma.2022.463186 000118283 0248_ $$2sideral$$a129617 000118283 037__ $$aART-2022-129617 000118283 041__ $$aeng 000118283 100__ $$aMarsol-Vall, A.$$uUniversidad de Zaragoza 000118283 245__ $$aDevelopment and validation of a method for the analysis of halophenols and haloanisoles in cork bark macerates by stir bar sorptive extraction heart-cutting two-dimensional gas chromatography negative chemical ionization mass spectrometry 000118283 260__ $$c2022 000118283 5060_ $$aAccess copy available to the general public$$fUnrestricted 000118283 5203_ $$aA method has been developed for the quantitative determination in cork bark macerates of 7halophenols and 5haloanisoles with demonstrated or suspected contribution to the cork taint off-flavour. Macerates were extracted with stirbar (20 mm polydimethylsiloxane-coated) sorptive extraction under optimized conditions (pH 3.5, 20% NaCl and 60 min). The bars were analysed byautomated thermal desorption, heart-cutting two-dimensional gas chromatography and negative chemical ionization-mass spectrometry. Matrix effects were compensated for by a “matrix matched” calibration curve. Limits of detection were in the range 0.03-0.24 ng L-1, below the corresponding odor thresholds. Linearity (0.983 = R2 = 0.998), intra- and inter-day precision (5.4-14.3%) and accuracy (89–126%) were satisfactory. The analysis of 48 natural cork bark samples affected/not-affected bya cryptogamic disease (yellow spot) revealed compositional differences in 2, 4, 6-trichloroanisole (2, 4, 6-TCA), 2, 4, 6-trichlorophenol (2, 4, 6-TCP) and also in 2, 6-dibromophenol, 2, 3, 4- and 2, 4, 5-TCP, 2, 3, 4-TCA and 2, 3, 4, 6-tetrachlorophenol (2, 3, 4, 6-TeCP). In addition, the contents of 2, 4, 6-TCP and 2, 4, 6-TCA, and 2, 3, 4, 6-TeCP and some TCPs presented strong linear correlations. 000118283 536__ $$9info:eu-repo/grantAgreement/ES/MICIU/FJCI-2018-035486-I 000118283 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000118283 590__ $$a4.1$$b2022 000118283 592__ $$a0.766$$b2022 000118283 591__ $$aCHEMISTRY, ANALYTICAL$$b25 / 86 = 0.291$$c2022$$dQ2$$eT1 000118283 593__ $$aAnalytical Chemistry$$c2022$$dQ1 000118283 591__ $$aBIOCHEMICAL RESEARCH METHODS$$b21 / 77 = 0.273$$c2022$$dQ2$$eT1 000118283 593__ $$aOrganic Chemistry$$c2022$$dQ1 000118283 593__ $$aMedicine (miscellaneous)$$c2022$$dQ2 000118283 593__ $$aBiochemistry$$c2022$$dQ2 000118283 594__ $$a7.4$$b2022 000118283 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000118283 700__ $$0(orcid)0000-0002-6348-5450$$aAinsa, S.$$uUniversidad de Zaragoza 000118283 700__ $$0(orcid)0000-0002-0730-6606$$aLópez, R.$$uUniversidad de Zaragoza 000118283 700__ $$0(orcid)0000-0002-4353-2483$$aFerreira, V.$$uUniversidad de Zaragoza 000118283 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica 000118283 773__ $$g1673 (2022), 463186 [8 pp.]$$pJ. chromatogr. A$$tJournal of Chromatography A$$x0021-9673 000118283 8564_ $$s1340948$$uhttps://zaguan.unizar.es/record/118283/files/texto_completo.pdf$$yVersión publicada 000118283 8564_ $$s2721417$$uhttps://zaguan.unizar.es/record/118283/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000118283 909CO $$ooai:zaguan.unizar.es:118283$$particulos$$pdriver 000118283 951__ $$a2024-03-18-16:14:42 000118283 980__ $$aARTICLE