Estudios
I+D+I
Institución
Internacional
Vida Universitaria
Atlantis Institut des Sciences Fictives
Recherche
Soumettre
Personnaliser
Vos alertes
Vos paniers
Vos recherches
Aide
EN
/
ES
Accueil
>
articulos
> A randomized study of nutritional supplementation in patients with unilateral wet age-related macular degeneration
Statistiques d'utilisation
Graphiques
A randomized study of nutritional supplementation in patients with unilateral wet age-related macular degeneration
García-Layana A.
;
Recalde S.
;
Hernandez M.
;
Abraldes M.J.
;
Nascimento J.
;
Hernández-Galilea E.
;
Olmedilla-Alonso B.
;
Escobar-Barranco J.J.
;
Zapata M.A.
;
Silva R.
;
Arredondo M.C.
;
Lopez-Sabater M.C.
;
Mendez-Martínez, S.
(Universidad de Zaragoza)
;
Pardiñas-Barón, N.
(Universidad de Zaragoza)
;
Calvo, P.
;
Fernández-Robredo P.
Resumen:
The purpose of this study is evaluate the efficacy and safety of medicinal products con-taining the original Age-Related Eye Disease group (AREDS) formulation at doses approved in Europe (EU, control group; n = 59) with a product that adds DHA, lutein, zeaxanthin, resveratrol and hydroxytyrosol to the formula (intervention group; n = 50). This was a multicenter, random-ized, observer-blinded trial conducted in patients aged 50 years or older diagnosed with unilateral exudative Age related Macular Degeneration AMD. At month 12, the intervention did not have a significant differential effect on visual acuity compared with the control group, with an estimated treatment difference in Early Treatment Diabetic Retinopathy Study (ETDRS) of -1.63 (95% CI -0.83 to 4.09; p = 0.192). The intervention exhibited a significant and, in most cases, relevant effect in terms of a reduction in some inflammatory cytokines and a greater improvement in the fatty acid profile and serum lutein and zeaxantin concentration. In patients with unilateral wet AMD, the addition of lutein, zeaxanthin, resveratrol, hydroxytyrosol and DHA to the AREDS EU recommended doses in the short-term did not have a differential effect on visual acuity compared to a standard AREDS EU formula but, in addition to improving the fatty acid profile and increasing carotenoid serum levels, may provide a beneficial effect in improving the proinflammatory and proangiogenic profile of patients with AMD. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Idioma:
Inglés
DOI:
10.3390/nu13041253
Año:
2021
Publicado en:
Nutrients
13, 4 (2021), 1253 [16 pp]
ISSN:
2072-6643
Factor impacto JCR:
6.706 (2021)
Categ. JCR:
NUTRITION & DIETETICS
rank: 15 / 90 = 0.167
(2021)
- Q1
- T1
Factor impacto CITESCORE:
7.9 -
Nursing
(Q1) -
Agricultural and Biological Sciences
(Q1)
Factor impacto SCIMAGO:
1.287 -
Nutrition and Dietetics
(Q1) -
Food Science
(Q1)
Tipo y forma:
Article (Published version)
Área (Departamento):
Area Medicina
(
Dpto. Medicina, Psiqu. y Derm.
)
Área (Departamento):
Área Oftalmología
(
Dpto. Cirugía
)
Exportado de SIDERAL (2023-05-18-15:40:28)
Permalink:
Copy
Visitas y descargas
Este artículo se encuentra en las siguientes colecciones:
articulos
Retour à la recherche
Notice créée le 2022-10-06, modifiée le 2023-05-19
Versión publicada:
PDF
Évaluer ce document:
Rate this document:
1
2
3
4
5
(Pas encore évalué)
Ajouter au panier personnel
Exporter vers
BibTeX
,
MARC
,
MARCXML
,
DC
,
EndNote
,
NLM
,
RefWorks