In vitro and in vivo biocompatibility of boron/nitrogen co-doped carbon nano-onions
Financiación H2020 / H2020 Funds
Resumen: Boron/nitrogen, co-doped, carbon nano-onions (BN-CNOs) have recently shown great promise as catalysts for the oxygen reduction reaction, due to the improved electronic properties imparted by the dopant atoms; however, the interactions of BN-CNOs with biological systems have not yet been explored. In this study, we examined the toxicological profiles of BN-CNOs and oxidized BN-CNOs (oxi-BN-CNOs) in vitro in both healthy and cancer cell lines, as well as on the embryonic stages of zebrafish (Danio rerio) in vivo. The cell viabilities of both cell lines cells were not affected after treatment with different concentrations of both doped CNO derivatives. On the other hand, the analysis of BN-CNOs and oxidized BN-CNO interactions with zebrafish embryos did not report any kind of perturbations, in agreement with the in vitro results. Our results show that both doped CNO derivatives possess a high biocompatibility and biosafety in cells and more complex systems. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Idioma: Inglés
DOI: 10.3390/nano11113017
Año: 2021
Publicado en: Nanomaterials 11, 11 (2021), 3017 [13 pp]
ISSN: 2079-4991

Factor impacto JCR: 5.719 (2021)
Categ. JCR: PHYSICS, APPLIED rank: 37 / 161 = 0.23 (2021) - Q1 - T1
Categ. JCR: MATERIALS SCIENCE, MULTIDISCIPLINARY rank: 109 / 345 = 0.316 (2021) - Q2 - T1
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 55 / 180 = 0.306 (2021) - Q2 - T1
Categ. JCR: NANOSCIENCE & NANOTECHNOLOGY rank: 53 / 109 = 0.486 (2021) - Q2 - T2

Factor impacto CITESCORE: 6.6 - Chemical Engineering (Q1) - Materials Science (Q1)

Factor impacto SCIMAGO: 0.839 - Materials Science (miscellaneous) (Q1) - Chemical Engineering (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/EC/H2020/823717/EU/Enabling Science and Technology through European Electron Microscopy/ESTEEM3
Tipo y forma: Article (Published version)

Creative Commons You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.


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