Atypical Lesions in Canine Leishmaniosis: Description of New Cases

Peris, María Paz (Universidad de Zaragoza) ; Ortega-Hernández, Paula ; Morales, Mariano (Universidad de Zaragoza) ; Castillo, Juan Antonio (Universidad de Zaragoza) ; Moreno, Bernardino (Universidad de Zaragoza)

Resumen: Pathological characteristics are well described in canine leishmaniosis (CanL). However, atypical lesions that can be confused with other pathologies or trigger unusual clinical signs are sporadically reported. Atypical lesions were observed during routine postmortem examination in three Leishmania-infected dogs and samples were taken for histopathological and immunohistochemical studies. Clinical signs, biochemical parameters, level of antibodies, and parasite detection by PCR were also evaluated. Atypical lesions were found in the peritoneal cavity, liver, and spleen. Splenomegalia and hepatomegalia were observed in all dogs. In addition, multifocal dark to white nodules of variable size were observed in the peritoneal cavity, liver, and spleen of one dog and in the spleen of the other two dogs. One dog presented diffuse irregular whitish lines with a threadlike appearance and another an intense fibrotic depression in the intermediate lobe. Microscopically, an intense granulomatous inflammation with abundant macrophages, a variable number of lymphocytes, and a low to moderate number of parasites was observed. This study represents the first description of granulomatous peritonitis associated with Leishmania in dogs. It also shows atypical macroscopic expression of hepatitis in CanL. In the absence of an adequate clinical history and laboratory analyses, certain lesions observed in CanL could admit alternative diagnoses.

Idioma: Inglés

DOI: 10.3390/ani12202784

Año: 2022

Publicado en: Animals 12, 20 (2022), 2784 [15 pp.]
ISSN: 2076-2615

Factor impacto JCR: 3.0 (2022)

Categ. JCR: VETERINARY SCIENCES rank: 13 / 144 = 0.09 (2022) - Q1 - T1
Categ. JCR: AGRICULTURE, DAIRY & ANIMAL SCIENCE rank: 12 / 62 = 0.194 (2022) - Q1 - T1

Factor impacto CITESCORE: 4.2 - Veterinary (Q1) - Agricultural and Biological Sciences (Q2)

Factor impacto SCIMAGO: 0.684 - Veterinary (miscellaneous) (Q1) - Animal Science and Zoology (Q1)

Financiación: info:eu-repo/grantAgreement/ES/DGA/A05-17R
Financiación: info:eu-repo/grantAgreement/ES/UZ-OTRI/2011-0093
Financiación: info:eu-repo/grantAgreement/ES/UZ-OTRI/2018-0008

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Sanidad Animal (Dpto. Patología Animal)