000120090 001__ 120090
000120090 005__ 20240319081018.0
000120090 0247_ $$2doi$$a10.3390/ani12202784
000120090 0248_ $$2sideral$$a130918
000120090 037__ $$aART-2022-130918
000120090 041__ $$aeng
000120090 100__ $$0(orcid)0000-0001-5750-3643$$aPeris, María Paz$$uUniversidad de Zaragoza
000120090 245__ $$aAtypical Lesions in Canine Leishmaniosis: Description of New Cases
000120090 260__ $$c2022
000120090 5060_ $$aAccess copy available to the general public$$fUnrestricted
000120090 5203_ $$aPathological characteristics are well described in canine leishmaniosis (CanL). However, atypical lesions that can be confused with other pathologies or trigger unusual clinical signs are sporadically reported. Atypical lesions were observed during routine postmortem examination in three Leishmania-infected dogs and samples were taken for histopathological and immunohistochemical studies. Clinical signs, biochemical parameters, level of antibodies, and parasite detection by PCR were also evaluated. Atypical lesions were found in the peritoneal cavity, liver, and spleen. Splenomegalia and hepatomegalia were observed in all dogs. In addition, multifocal dark to white nodules of variable size were observed in the peritoneal cavity, liver, and spleen of one dog and in the spleen of the other two dogs. One dog presented diffuse irregular whitish lines with a threadlike appearance and another an intense fibrotic depression in the intermediate lobe. Microscopically, an intense granulomatous inflammation with abundant macrophages, a variable number of lymphocytes, and a low to moderate number of parasites was observed. This study represents the first description of granulomatous peritonitis associated with Leishmania in dogs. It also shows atypical macroscopic expression of hepatitis in CanL. In the absence of an adequate clinical history and laboratory analyses, certain lesions observed in CanL could admit alternative diagnoses.
000120090 536__ $$9info:eu-repo/grantAgreement/ES/DGA/A05-17R$$9info:eu-repo/grantAgreement/ES/UZ-OTRI/2011-0093$$9info:eu-repo/grantAgreement/ES/UZ-OTRI/2018-0008
000120090 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000120090 590__ $$a3.0$$b2022
000120090 592__ $$a0.684$$b2022
000120090 591__ $$aVETERINARY SCIENCES$$b13 / 144 = 0.09$$c2022$$dQ1$$eT1
000120090 593__ $$aVeterinary (miscellaneous)$$c2022$$dQ1
000120090 591__ $$aAGRICULTURE, DAIRY & ANIMAL SCIENCE$$b12 / 62 = 0.194$$c2022$$dQ1$$eT1
000120090 593__ $$aAnimal Science and Zoology$$c2022$$dQ1
000120090 594__ $$a4.2$$b2022
000120090 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000120090 700__ $$0(orcid)0000-0001-7331-2863$$aOrtega-Hernández, Paula
000120090 700__ $$0(orcid)0000-0001-9778-6545$$aMorales, Mariano$$uUniversidad de Zaragoza
000120090 700__ $$0(orcid)0000-0002-2048-4749$$aCastillo, Juan Antonio$$uUniversidad de Zaragoza
000120090 700__ $$0(orcid)0000-0001-6629-6842$$aMoreno, Bernardino$$uUniversidad de Zaragoza
000120090 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000120090 773__ $$g12, 20 (2022), 2784 [15 pp.]$$pAnimals (Basel)$$tAnimals$$x2076-2615
000120090 8564_ $$s2226417$$uhttps://zaguan.unizar.es/record/120090/files/texto_completo.pdf$$yVersión publicada
000120090 8564_ $$s2777305$$uhttps://zaguan.unizar.es/record/120090/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000120090 909CO $$ooai:zaguan.unizar.es:120090$$particulos$$pdriver
000120090 951__ $$a2024-03-18-15:55:15
000120090 980__ $$aARTICLE