Speckle Contrast as Retinal Tissue Integrity Biomarker in Patients with Type 1 Diabetes Mellitus with No Retinopathy

Orduna-Hospital, Elvira (Universidad de Zaragoza) ; Arcas-Carbonell, Maria ; Sanchez-Cano, Ana (Universidad de Zaragoza) ; Pinilla, Isabel (Universidad de Zaragoza) ; Consejo, Alejandra (Universidad de Zaragoza)

Resumen: Purpose: To study the retinal and choroidal layers in type 1 diabetes mellitus (DM1) without diabetic retinopathy (DR), using speckle contrast of optical coherence tomography (OCT) images as a tissue biomarker in comparison with healthy subjects. Methods: OCT Spectralis images of 148 eyes, 84 from DM1 patients without DR signs, and 64 belonging to the control group, were collected. The speckle contrast and thickness of the inner retinal layer (IRL), the outer retinal layer (ORL), and the choroidal layer in the nasal parafoveal area (N3), were prospectively analyzed. Results: A statistically significant difference (p = 0.001) in the IRL thickness between groups was observed, being thicker in the DM1 group. There were no differences in the ORL and choroidal thicknesses between groups. A statistically significant difference (p = 0.02) in the IRL speckle contrast was obtained, being lower in the DM1 group. The maximum speckle contrast was reached in the ORL for both groups, although in the DM1 group, it occurs closer to the choroid, at 64 ± 8 μm (p = 0.008). Conclusions: Statistically significant differences were found in speckle contrast and thickness between the control and the DM1 group, suggesting an IRL alteration of DM1 patients, supporting the retinal neurodegeneration before DR signs are observed.

Idioma: Inglés

DOI: 10.3390/jpm12111807

Año: 2022

Publicado en: Journal of Personalized Medicine 12, 11 (2022), 1807 [10 pp.]
ISSN: 2075-4426

Factor impacto JCR: 3.4 (2022)

Categ. JCR: MEDICINE, GENERAL & INTERNAL rank: 67 / 169 = 0.396 (2022) - Q2 - T2
Categ. JCR: HEALTH CARE SCIENCES & SERVICES rank: 42 / 106 = 0.396 (2022) - Q2 - T2

Factor impacto CITESCORE: 2.6 - Medicine (Q3)

Factor impacto SCIMAGO: 0.665 - Medicine (miscellaneous) (Q2)

Financiación: info:eu-repo/grantAgreement/ES/DGA/B08-20R
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI20-00740

Tipo y forma: Article (Published version)

Área (Departamento): Área Física Aplicada (Dpto. Física Aplicada)
Área (Departamento): Área Oftalmología (Dpto. Cirugía)
Área (Departamento): Área Óptica (Dpto. Física Aplicada)