Longitudinal associations between cardiovascular biomarkers and metabolic syndrome during puberty: the PUBMEP study

González-Gil, Esther M. ; Anguita-Ruiz, Augusto ; Kalén, Anton ; De las Lamas Perez, Carmela ; Rupérez, Azahara I. ; Vázquez-Cobela, Rocio ; Flores, Katherine ; Gil, Angel ; Gil-Campos, Mercedes ; Bueno, Gloria (Universidad de Zaragoza) ; Leis, Rosaura ; Aguilera, Concepción M.

Resumen: Puberty has been described as a life stage of considerable metabolic risk specially for those with obesity. The low-grade systemic inflammatory status associated with obesity could be one of the connections with metabolic syndrome (MetS). Thus, we aimed to assess the relationship between inflammatory and cardiovascular biomarkers and the development of MetS during puberty. Seventy-five children from the PUBMEP study (33 females), aged 4–18 years, were included. Cardiovascular and inflammatory biomarkers were measured in the prepubertal and pubertal stage, including high-sensitivity C-reactive protein (CRP), leptin, tumor necrosis factor-alpha (TNFα), interleukin 8 (IL8), monocyte chemoattractant protein 1 (MCP-1), total plasminogen activator inhibitor-1 (tPAI), resistin, adiponectin, myeloperoxidase (MPO), and soluble intercellular adhesion molecule-1 (sICAM-1). MetS was diagnosed at each measurement point. Mixed-effects and logistic regressions were performed. Those children with MetS in puberty presented higher prepubertal values of several cardiometabolic biomarkers in comparison to those without MetS (z-score body mass index (zBMI), waist circumference, insulin, HOMA-IR, leptin, and tPAI (p < 0.05)). For prepubertal children with obesity, the odds of developing MetS in puberty were significantly higher in those having high zBMI (OR = 4.27; CI: 1.39–22.59) or high concentrations of tPAI (OR = 1.19; CI: 1.06–1.43)

Idioma: Inglés

DOI: 10.1007/s00431-022-04702-6

Año: 2023

Publicado en: European Journal of Pediatrics 182, 1 (2023), 419–429
ISSN: 0340-6199

Factor impacto JCR: 3.0 (2023)

Categ. JCR: PEDIATRICS rank: 26 / 186 = 0.14 (2023) - Q1 - T1

Factor impacto CITESCORE: 5.9 - Pediatrics, Perinatology and Child Health (Q1)

Factor impacto SCIMAGO: 0.984 - Pediatrics, Perinatology and Child Health (Q1)

Financiación: info:eu-repo/grantAgreement/ES/CIBERObn/CB15-00043
Financiación: info:eu-repo/grantAgreement/ES/CIBERObn/CB15-00131
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-01425
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-02042
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-02059
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-00871
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-01205
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-01301
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI20-00563

Tipo y forma: Article (Published version)

Área (Departamento): Área Pediatría (Dpto. Microb.Ped.Radio.Sal.Pú.)