000120208 001__ 120208 000120208 005__ 20240319081019.0 000120208 0247_ $$2doi$$a10.3390/ani12233341 000120208 0248_ $$2sideral$$a131048 000120208 037__ $$aART-2022-131048 000120208 041__ $$aeng 000120208 100__ $$0(orcid)0000-0001-6209-4282$$aVillanueva-Saz, Sergio$$uUniversidad de Zaragoza 000120208 245__ $$aAnaemia in Sheep Caused by Babesia and Theileria Haemoparasites 000120208 260__ $$c2022 000120208 5060_ $$aAccess copy available to the general public$$fUnrestricted 000120208 5203_ $$aPiroplasmoses in sheep are caused by vector-borne apicomplexan protozoa, Babesia and Theileria. Different species are responsible for the disease; some species are more pathogenic than others and have a worldwide distribution. In this sense, these causative agents can cause anaemia in flocks. In general, these vector-borne diseases infect small ruminants and cause host-mediated pathology. In the case of Babesia species, a combination of different mechanisms is involved: red blood cell lysis due to intracellular parasite multiplication, activation of biogenic amines and the coagulation system with the possibility of disseminated intravascular coagulation. By contrast, less information is available on the different immunopathogenic mechanisms involved in the development of anaemia in sheep with theileriosis. However, the mechanisms of pathogenic action in theileriosis are similar to those studied in babesiosis. Diagnosis is based on compatible clinical signs, laboratory findings, specific diagnostic tests and the presence of the tick vector. Some of these tests detect the causative agent itself, such as direct identification by light microscopy and molecular analysis. In contrast, other tests detect the sheep’s immune response to the organism by serology. Both diseases pose a significant diagnostic challenge for veterinary practitioners around the world. This review presents the most frequent clinical signs, pathogenesis and clinicopathological findings, diagnosis. 000120208 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000120208 590__ $$a3.0$$b2022 000120208 592__ $$a0.684$$b2022 000120208 591__ $$aVETERINARY SCIENCES$$b13 / 144 = 0.09$$c2022$$dQ1$$eT1 000120208 593__ $$aVeterinary (miscellaneous)$$c2022$$dQ1 000120208 591__ $$aAGRICULTURE, DAIRY & ANIMAL SCIENCE$$b12 / 62 = 0.194$$c2022$$dQ1$$eT1 000120208 593__ $$aAnimal Science and Zoology$$c2022$$dQ1 000120208 594__ $$a4.2$$b2022 000120208 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000120208 700__ $$0(orcid)0000-0002-0680-9957$$aBorobia, Marta$$uUniversidad de Zaragoza 000120208 700__ $$0(orcid)0000-0002-2557-4890$$aFernández, Antonio$$uUniversidad de Zaragoza 000120208 700__ $$aJiménez, Calasanz 000120208 700__ $$aYzuel, Andrés 000120208 700__ $$0(orcid)0000-0003-2957-1379$$aVerde, María Teresa$$uUniversidad de Zaragoza 000120208 700__ $$0(orcid)0000-0002-6282-5038$$aRamo, María Ángeles$$uUniversidad de Zaragoza 000120208 700__ $$0(orcid)0000-0002-5477-8534$$aFigueras, Luis$$uUniversidad de Zaragoza 000120208 700__ $$0(orcid)0000-0002-8474-2831$$aRuíz, Héctor$$uUniversidad de Zaragoza 000120208 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal 000120208 773__ $$g12, 23 (2022), 3341 [15 pp.]$$pAnimals (Basel)$$tAnimals$$x2076-2615 000120208 8564_ $$s2133868$$uhttps://zaguan.unizar.es/record/120208/files/texto_completo.pdf$$yVersión publicada 000120208 8564_ $$s2685036$$uhttps://zaguan.unizar.es/record/120208/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000120208 909CO $$ooai:zaguan.unizar.es:120208$$particulos$$pdriver 000120208 951__ $$a2024-03-18-16:01:38 000120208 980__ $$aARTICLE