Thresholds of handgrip strength for all-cause, cancer, and cardiovascular mortality: A systematic review with dose-response meta-analysis
López-Bueno, Rubén ; Andersen, Lars Louis ; Koyanagi, Ai ; Núñez-Cortés, Rodrigo ; Calatayud, Joaquín ; Casaña, José ; del Pozo Cruz, Borja
Resumen: Background
While handgrip strength is associated with all-cause and cause-specific mortality, whether such associations are dose-dependent is largely unknown. Therefore, we conducted a systematic review on the dose-response relationship of handgrip strength with all-cause mortality, cancer, and cardiovascular mortality.
Methods
The data source included three electronic databases (PubMed/MEDLINE, Web of Science and Scopus) from inception to 8 February 2022. Prospective cohort studies of healthy adults with objective measures of handgrip strength were included. Two researchers independently screened studies, extracted data, and assessed risk of bias. We used estimates regarding handgrip strength categories to conduct a random forest model, and a two-stage random-effects hierarchical meta-regression model pooling study-specific estimates for dose-response relationship. Outcomes included all-cause, cancer, and cardiovascular mortality.
Reults
Forty-eight studies comprising 3,135,473 participants (49.6% women, age range 35–85 years) were included. Random forest models showed a significant inverse association between handgrip strength and all-cause and cause-specific mortality. Dose-response meta-analyses showed that higher levels of handgrip strength significantly reduced the risk of all-cause mortality within 26–50 kg (Higgin´s I2 =45.7%) in a close-to-linear inverse fashion. Cancer and cardiovascular mortality displayed a trend towards a U-shaped association with a significant risk reduction between 16 and 33 kg (Higgin´s I2 =77.4%), and a close-to-linear inverse shaped and significant risk reduction ranging from 24 to 40 kg (Higgin´s I2 =79.7%) respectively.
Conclusion
There is strong evidence for an association between lower handgrip strength with higher all-cause, cancer, and cardiovascular mortality risk. The dose-response relationship of handgrip strength substantially varies depending on the cause of mortality.
Idioma: Inglés
DOI: 10.1016/j.arr.2022.101778
Año: 2022
Publicado en: Ageing Research Reviews 82 (2022), 101778 [12 pp.]
ISSN: 1568-1637
Factor impacto JCR: 13.1 (2022)
Categ. JCR: GERIATRICS & GERONTOLOGY rank: 1 / 54 = 0.019 (2022) - Q1 - T1
Categ. JCR: CELL BIOLOGY rank: 20 / 191 = 0.105 (2022) - Q1 - T1
Factor impacto CITESCORE: 17.5 - Neuroscience (Q1) - Biochemistry, Genetics and Molecular Biology (Q1)
Factor impacto SCIMAGO: 3.007 - Aging (Q1) - Biochemistry (Q1) - Neurology (Q1) - Molecular Biology (Q1) - Biotechnology (Q1)
Tipo y forma: Article (Published version)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material.
Exportado de SIDERAL (2024-03-18-14:22:34)
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While handgrip strength is associated with all-cause and cause-specific mortality, whether such associations are dose-dependent is largely unknown. Therefore, we conducted a systematic review on the dose-response relationship of handgrip strength with all-cause mortality, cancer, and cardiovascular mortality.
Methods
The data source included three electronic databases (PubMed/MEDLINE, Web of Science and Scopus) from inception to 8 February 2022. Prospective cohort studies of healthy adults with objective measures of handgrip strength were included. Two researchers independently screened studies, extracted data, and assessed risk of bias. We used estimates regarding handgrip strength categories to conduct a random forest model, and a two-stage random-effects hierarchical meta-regression model pooling study-specific estimates for dose-response relationship. Outcomes included all-cause, cancer, and cardiovascular mortality.
Reults
Forty-eight studies comprising 3,135,473 participants (49.6% women, age range 35–85 years) were included. Random forest models showed a significant inverse association between handgrip strength and all-cause and cause-specific mortality. Dose-response meta-analyses showed that higher levels of handgrip strength significantly reduced the risk of all-cause mortality within 26–50 kg (Higgin´s I2 =45.7%) in a close-to-linear inverse fashion. Cancer and cardiovascular mortality displayed a trend towards a U-shaped association with a significant risk reduction between 16 and 33 kg (Higgin´s I2 =77.4%), and a close-to-linear inverse shaped and significant risk reduction ranging from 24 to 40 kg (Higgin´s I2 =79.7%) respectively.
Conclusion
There is strong evidence for an association between lower handgrip strength with higher all-cause, cancer, and cardiovascular mortality risk. The dose-response relationship of handgrip strength substantially varies depending on the cause of mortality.
Idioma: Inglés
DOI: 10.1016/j.arr.2022.101778
Año: 2022
Publicado en: Ageing Research Reviews 82 (2022), 101778 [12 pp.]
ISSN: 1568-1637
Factor impacto JCR: 13.1 (2022)
Categ. JCR: GERIATRICS & GERONTOLOGY rank: 1 / 54 = 0.019 (2022) - Q1 - T1
Categ. JCR: CELL BIOLOGY rank: 20 / 191 = 0.105 (2022) - Q1 - T1
Factor impacto CITESCORE: 17.5 - Neuroscience (Q1) - Biochemistry, Genetics and Molecular Biology (Q1)
Factor impacto SCIMAGO: 3.007 - Aging (Q1) - Biochemistry (Q1) - Neurology (Q1) - Molecular Biology (Q1) - Biotechnology (Q1)
Tipo y forma: Article (Published version)
You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. If you remix, transform, or build upon the material, you may not distribute the modified material. Exportado de SIDERAL (2024-03-18-14:22:34)
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Record created 2022-12-21, last modified 2024-03-19