Analysis of Retinal Layers in Fibromyalgia Patients with Premium Protocol in Optical Tomography Coherence and Quality of Life

Cordon, B. (Universidad de Zaragoza) ; Orduna, E. (Universidad de Zaragoza) ; Viladés, E. (Universidad de Zaragoza) ; Garcia-Martin, E (Universidad de Zaragoza) ; Garcia-Campayo, J. (Universidad de Zaragoza) ; Puebla-Guedea, M. (Universidad de Zaragoza) ; Polo, V. (Universidad de Zaragoza) ; Larrosa, J.M. (Universidad de Zaragoza) ; Pablo, L.E. (Universidad de Zaragoza) ; Vicente, M.J. ; Satue, M. (Universidad de Zaragoza)

Resumen: Purpose To evaluate the inner retinal layers in fibromyalgia (FM) patients compared to control subjects using posterior pole protocol (PPole) analysis in optical coherence tomography (OCT) and to correlate structural retinal changes with subjective quality of life. Methods Seventy-four eyes of healthy subjects and 55 eyes of those with FM were analyzed. All subjects underwent retinal evaluation using the PPole protocol for Spectralis OCT (Heidelberg Engineering) to obtain measurements of the retinal nerve fiber layer (RNFL) and the ganglion cell layer (GCL) in the macular area. The EuroQol (EQ-5D) questionnaire and Fibromyalgia Impact Questionnaire (FIQ) were performed to analyze health-related quality of life. Additionally, the FM group was divided into three groups depending on the disease phenotype (atypical, depressive, and biological). Results Patients with FM presented with a reduction of the RNFL thickness compared to controls in 17/64 cells of the PPole area, and a reduction of the GCL thickness in 47/64 cells. Depressive FM phenotype showed the greatest number of cells with significant reduction compared with the control group in both RNFL and GCL layers. A correlation between temporal-inferior cells of the GCL and the EuroQol 5D questionnaire results was observed. Conclusions Patients with FM present with a reduction of the inner retinal layers in the macular area. This degeneration correlates with disease severity/reduced quality of life in these patients. The PPole protocol for OCT is a non-invasive and fast tool that might help clinicians diagnose and monitor neurodegeneration in FM patients.

Idioma: Inglés

DOI: 10.1080/02713683.2021.1951301

Año: 2022

Publicado en: CURRENT EYE RESEARCH 47, 1 (2022), 143-153
ISSN: 0271-3683

Factor impacto JCR: 2.0 (2022)

Categ. JCR: OPHTHALMOLOGY rank: 37 / 62 = 0.597 (2022) - Q3 - T2

Factor impacto CITESCORE: 4.3 - Neuroscience (Q3) - Medicine (Q2)

Factor impacto SCIMAGO: 0.639 - Ophthalmology (Q2) - Sensory Systems (Q3) - Cellular and Molecular Neuroscience (Q4)

Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI17-01726
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI17-01946
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI20-00437
Financiación: info:eu-repo/grantAgreement/ES/MINECO/MAT2017-83858-C2-2

Tipo y forma: Artículo (PostPrint)

Área (Departamento): Área Oftalmología (Dpto. Cirugía)
Área (Departamento): Area Psiquiatría (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Óptica (Dpto. Física Aplicada)
Área (Departamento): Área Psicolog.Evolut.Educac (Dpto. Psicología y Sociología)