000121070 001__ 121070
000121070 005__ 20240319080948.0
000121070 0247_ $$2doi$$a10.1080/02713683.2021.1951301
000121070 0248_ $$2sideral$$a126075
000121070 037__ $$aART-2022-126075
000121070 041__ $$aeng
000121070 100__ $$aCordon, B.$$uUniversidad de Zaragoza
000121070 245__ $$aAnalysis of Retinal Layers in Fibromyalgia Patients with Premium Protocol in Optical Tomography Coherence and Quality of Life
000121070 260__ $$c2022
000121070 5060_ $$aAccess copy available to the general public$$fUnrestricted
000121070 5203_ $$aPurpose To evaluate the inner retinal layers in fibromyalgia (FM) patients compared to control subjects using posterior pole protocol (PPole) analysis in optical coherence tomography (OCT) and to correlate structural retinal changes with subjective quality of life. Methods Seventy-four eyes of healthy subjects and 55 eyes of those with FM were analyzed. All subjects underwent retinal evaluation using the PPole protocol for Spectralis OCT (Heidelberg Engineering) to obtain measurements of the retinal nerve fiber layer (RNFL) and the ganglion cell layer (GCL) in the macular area. The EuroQol (EQ-5D) questionnaire and Fibromyalgia Impact Questionnaire (FIQ) were performed to analyze health-related quality of life. Additionally, the FM group was divided into three groups depending on the disease phenotype (atypical, depressive, and biological). Results Patients with FM presented with a reduction of the RNFL thickness compared to controls in 17/64 cells of the PPole area, and a reduction of the GCL thickness in 47/64 cells. Depressive FM phenotype showed the greatest number of cells with significant reduction compared with the control group in both RNFL and GCL layers. A correlation between temporal-inferior cells of the GCL and the EuroQol 5D questionnaire results was observed. Conclusions Patients with FM present with a reduction of the inner retinal layers in the macular area. This degeneration correlates with disease severity/reduced quality of life in these patients. The PPole protocol for OCT is a non-invasive and fast tool that might help clinicians diagnose and monitor neurodegeneration in FM patients.
000121070 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI17-01726$$9info:eu-repo/grantAgreement/ES/ISCIII/PI17-01946$$9info:eu-repo/grantAgreement/ES/ISCIII/PI20-00437$$9info:eu-repo/grantAgreement/ES/MINECO/MAT2017-83858-C2-2
000121070 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000121070 590__ $$a2.0$$b2022
000121070 592__ $$a0.639$$b2022
000121070 591__ $$aOPHTHALMOLOGY$$b37 / 62 = 0.597$$c2022$$dQ3$$eT2
000121070 593__ $$aOphthalmology$$c2022$$dQ2
000121070 593__ $$aSensory Systems$$c2022$$dQ3
000121070 593__ $$aCellular and Molecular Neuroscience$$c2022$$dQ4
000121070 594__ $$a4.3$$b2022
000121070 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000121070 700__ $$0(orcid)0000-0003-2710-1875$$aOrduna, E.$$uUniversidad de Zaragoza
000121070 700__ $$0(orcid)0000-0001-9411-5834$$aViladés, E.$$uUniversidad de Zaragoza
000121070 700__ $$0(orcid)0000-0001-6258-2489$$aGarcia-Martin, E$$uUniversidad de Zaragoza
000121070 700__ $$0(orcid)0000-0002-3797-4218$$aGarcia-Campayo, J.$$uUniversidad de Zaragoza
000121070 700__ $$0(orcid)0000-0002-8862-7240$$aPuebla-Guedea, M.$$uUniversidad de Zaragoza
000121070 700__ $$0(orcid)0000-0002-1402-3129$$aPolo, V.$$uUniversidad de Zaragoza
000121070 700__ $$0(orcid)0000-0002-6745-7668$$aLarrosa, J.M.$$uUniversidad de Zaragoza
000121070 700__ $$0(orcid)0000-0003-2389-8282$$aPablo, L.E.$$uUniversidad de Zaragoza
000121070 700__ $$aVicente, M.J.
000121070 700__ $$0(orcid)0000-0002-1609-5994$$aSatue, M.$$uUniversidad de Zaragoza
000121070 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000121070 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000121070 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000121070 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac
000121070 773__ $$g47, 1 (2022), 143-153$$pCurr. eye res.$$tCURRENT EYE RESEARCH$$x0271-3683
000121070 8564_ $$s1535269$$uhttps://zaguan.unizar.es/record/121070/files/texto_completo.pdf$$yPostprint
000121070 8564_ $$s1161133$$uhttps://zaguan.unizar.es/record/121070/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000121070 909CO $$ooai:zaguan.unizar.es:121070$$particulos$$pdriver
000121070 951__ $$a2024-03-18-12:46:03
000121070 980__ $$aARTICLE