Blunted autonomic reactivity to mental stress in depression quantified by nonlinear cardiorespiratory coupling indices

Kontaxis, Spyridon (Universidad de Zaragoza) ; Laguna, Pablo (Universidad de Zaragoza) ; García Pages, Esther ; Posadas-de Miguel, Mar ; Siddi, Sara ; Luisa Bernal, Maria (Universidad de Zaragoza) ; Maria Haro, Josep ; Aguiló, Jordi ; de la Camara, Concepción (Universidad de Zaragoza) ; Bailón, Raquel (Universidad de Zaragoza) ; Gil, Eduardo (Universidad de Zaragoza)

Resumen: In this study, differences in autonomic reactivity to mental stress between Major Depressive Disorder (MDD) patients and healthy control (HC) subjects are assessed by nonlinear cardiorespiratory coupling indices derived from the Real Wavelet Biphase. The degree and strength of Quadratic Phase Coupling (QPC) between interacting oscillations of Heart Rate Variability (HRV) and respiration are quantified before, during and after the execution of acognitive task. Results show that the QPC strength and QPC degree between the respiration and the respiratory sinus arrhythmia component of HRV were lower in HC compared to MDD during stress, suggesting that the parasympathetic branch was less inhibited in MDD patients. During recovery, only in HC group, this degree of QPC increased, while the respiratory rate was reduced, compared to the basal stage. The degree of QPC between the respiration and components of HRV in the low frequency band ([0.04, 0.15] Hz) increased in HC during stress, compared to the basal stage, while remained unchanged in MDD patients. These results imply that depression is associated with blunted autonomic reactivity to mental stress

Idioma: Inglés

DOI: 10.22489/CinC.2020.233

Año: 2020

Publicado en: Computing in Cardiology 47 (2020), [4 pp.]
ISSN: 2325-8861

Factor impacto SCIMAGO: 0.257 - Computer Science (miscellaneous) - Cardiology and Cardiovascular Medicine

Financiación: info:eu-repo/grantAgreement/ES/AEI-FEDER/RTI2018-097723-B-I00
Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/LMP44-18
Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R-BSICoS group
Financiación: info:eu-repo/grantAgreement/ES/UZ/ICTS NANBIOSIS-CIBER-BBN

Tipo y forma: Article (Published version)

Área (Departamento): Área Ingen.Sistemas y Automát. (Dpto. Informát.Ingenie.Sistms.)
Área (Departamento): Área Farmacología (Dpto. Farmac.Fisiol.y Med.L.F.)
Área (Departamento): Área Teoría Señal y Comunicac. (Dpto. Ingeniería Electrón.Com.)
Área (Departamento): Area Psiquiatría (Dpto. Medicina, Psiqu. y Derm.)