000121380 001__ 121380
000121380 005__ 20241125101127.0
000121380 0247_ $$2doi$$a10.3390/ijms24010471
000121380 0248_ $$2sideral$$a131894
000121380 037__ $$aART-2023-131894
000121380 041__ $$aeng
000121380 100__ $$0(orcid)0000-0002-0269-7337$$aRuiz Pesini, Eduardo$$uUniversidad de Zaragoza
000121380 245__ $$aMitochondrial genetic background may impact statins side effects and atherosclerosis development in familial hypercholesterolemia
000121380 260__ $$c2023
000121380 5060_ $$aAccess copy available to the general public$$fUnrestricted
000121380 5203_ $$aHeredity of familial hypercholesterolemia (FH) can present as a dominant monogenic disorder of polygenic origin or with no known genetic cause. In addition, the variability of the symptoms among individuals or within the same families evidence the potential contribution of additional factors than monogenic mutations that could modulate the development and severity of the disease. In addition, statins, the lipid-lowering drugs which constitute the first-line therapy for the disease, cause associated muscular symptoms in a certain number of individuals. Here, we analyze the evidence of the mitochondrial genetic variation with a special emphasis on the role of CoQ10 to explain this variability found in both disease symptoms and statins side effects. We propose to use mtDNA variants and copy numbers as markers for the cardiovascular disease development of FH patients and to predict potential statin secondary effects and explore new mechanisms to identify new markers of disease or implement personalized medicine strategies for FH therapy.
000121380 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B33-20R$$9info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón$$9info:eu-repo/grantAgreement/ES/DGA/LMP22_21$$9info:eu-repo/grantAgreement/EUR/ERDF-ESF/Investing in your future$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI21-00229$$9info:eu-repo/grantAgreement/ES/MICINN/PID2020-116970GA-I00$$9info:eu-repo/grantAgreement/ES/MICINN/RYC2020-029544-I
000121380 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000121380 590__ $$a4.9$$b2023
000121380 592__ $$a1.179$$b2023
000121380 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b66 / 313 = 0.211$$c2023$$dQ1$$eT1
000121380 593__ $$aMedicine (miscellaneous)$$c2023$$dQ1
000121380 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b68 / 231 = 0.294$$c2023$$dQ2$$eT1
000121380 593__ $$aPhysical and Theoretical Chemistry$$c2023$$dQ1
000121380 593__ $$aComputer Science Applications$$c2023$$dQ1
000121380 593__ $$aInorganic Chemistry$$c2023$$dQ1
000121380 593__ $$aSpectroscopy$$c2023$$dQ1
000121380 593__ $$aOrganic Chemistry$$c2023$$dQ1
000121380 593__ $$aMolecular Biology$$c2023$$dQ2
000121380 593__ $$aCatalysis$$c2023$$dQ2
000121380 594__ $$a8.1$$b2023
000121380 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000121380 700__ $$0(orcid)0000-0002-8585-6371$$aBayona Bafaluy, María Pilar$$uUniversidad de Zaragoza
000121380 700__ $$0(orcid)0000-0002-5407-3876$$aSanclemente, Teresa$$uUniversidad de Zaragoza
000121380 700__ $$0(orcid)0000-0002-1309-4363$$aPuzo, José$$uUniversidad de Zaragoza
000121380 700__ $$0(orcid)0000-0003-1770-6299$$aMontoya, Julio$$uUniversidad de Zaragoza
000121380 700__ $$0(orcid)0000-0003-2645-3983$$aPacheu Grau, David$$uUniversidad de Zaragoza
000121380 7102_ $$12008$$2640$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Nutrición Bromatología
000121380 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000121380 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000121380 773__ $$g24, 1 (2023), 471 [10 pp.]$$pInt. j. mol. sci.$$tInternational Journal of Molecular Sciences$$x1661-6596
000121380 8564_ $$s293158$$uhttps://zaguan.unizar.es/record/121380/files/texto_completo.pdf$$yVersión publicada
000121380 8564_ $$s2781530$$uhttps://zaguan.unizar.es/record/121380/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000121380 909CO $$ooai:zaguan.unizar.es:121380$$particulos$$pdriver
000121380 951__ $$a2024-11-22-11:57:52
000121380 980__ $$aARTICLE