Mitochondrial genetic background may impact statins side effects and atherosclerosis development in familial hypercholesterolemia

Ruiz Pesini, Eduardo (Universidad de Zaragoza) ; Bayona Bafaluy, María Pilar (Universidad de Zaragoza) ; Sanclemente, Teresa (Universidad de Zaragoza) ; Puzo, José (Universidad de Zaragoza) ; Montoya, Julio (Universidad de Zaragoza) ; Pacheu Grau, David (Universidad de Zaragoza)

Resumen: Heredity of familial hypercholesterolemia (FH) can present as a dominant monogenic disorder of polygenic origin or with no known genetic cause. In addition, the variability of the symptoms among individuals or within the same families evidence the potential contribution of additional factors than monogenic mutations that could modulate the development and severity of the disease. In addition, statins, the lipid-lowering drugs which constitute the first-line therapy for the disease, cause associated muscular symptoms in a certain number of individuals. Here, we analyze the evidence of the mitochondrial genetic variation with a special emphasis on the role of CoQ10 to explain this variability found in both disease symptoms and statins side effects. We propose to use mtDNA variants and copy numbers as markers for the cardiovascular disease development of FH patients and to predict potential statin secondary effects and explore new mechanisms to identify new markers of disease or implement personalized medicine strategies for FH therapy.

Idioma: Inglés

DOI: 10.3390/ijms24010471

Año: 2023

Publicado en: International Journal of Molecular Sciences 24, 1 (2023), 471 [10 pp.]
ISSN: 1661-6596

Financiación: info:eu-repo/grantAgreement/ES/DGA/B33-20R
Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón
Financiación: info:eu-repo/grantAgreement/ES/DGA/LMP22_21
Financiación: info:eu-repo/grantAgreement/EUR/ERDF-ESF/Investing in your future
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI21-00229
Financiación: info:eu-repo/grantAgreement/ES/MICINN/PID2020-116970GA-I00
Financiación: info:eu-repo/grantAgreement/ES/MICINN/RYC2020-029544-I

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Nutrición Bromatología (Dpto. Produc.Animal Cienc.Ali.)
Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)
Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)