000124045 001__ 124045
000124045 005__ 20231127095534.0
000124045 0247_ $$2doi$$a10.1016/j.ijpharm.2023.122589
000124045 0248_ $$2sideral$$a132671
000124045 037__ $$aART-2023-132671
000124045 041__ $$aeng
000124045 100__ $$0(orcid)0000-0001-6139-5905$$aPaz-Artigas, L.
000124045 245__ $$aCurrent approaches for the recreation of cardiac ischaemic environment in vitro
000124045 260__ $$c2023
000124045 5060_ $$aAccess copy available to the general public$$fUnrestricted
000124045 5203_ $$aMyocardial ischaemia is one of the leading dead causes worldwide. Although animal experiments have historically provided a wealth of information, animal models are time and money consuming, and they usually miss typical human patient’s characteristics associated with ischemia prevalence, including aging and comorbidities. Generating reliable in vitro models that recapitulate the human cardiac microenvironment during an ischaemic event can boost the development of new drugs and therapeutic strategies, as well as our understanding of the underlying cellular and molecular events, helping the optimization of therapeutic approaches prior to animal and clinical testing. Although several culture systems have emerged for the recreation of cardiac physiology, mimicking the features of an ischaemic heart tissue in vitro is challenging and certain aspects of the disease process remain poorly addressed. Here, current in vitro cardiac culture systems used for modelling cardiac ischaemia, from self-aggregated organoids to scaffold-based constructs and heart-on-chip platforms are described. The advantages of these models to recreate ischaemic hallmarks such as oxygen gradients, pathological alterations of mechanical strength or fibrotic responses are highlighted. The new models represent a step forward to be considered, but unfortunately, we are far away from recapitulating all complexity of the clinical situations.
000124045 536__ $$9info:eu-repo/grantAgreement/EC/H2020/778354/EU/Heart On chip based on induced pluripotent Stem cell Technology for personalized Medicine/CISTEM$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 778354-CISTEM$$9info:eu-repo/grantAgreement/EC/H2020/829010/EU/Advanced and versatile PRInting platform for the next generation of active Microfluidic dEvices/PRIME$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 829010-PRIME$$9info:eu-repo/grantAgreement/EC/H2020/874827/EU/Computational biomechanics and bioengineering 3D printing to develop a personalized regenerative biological ventricular assist device to provide lasting functional support to damaged hearts/BRAV3$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 874827-BRAV3$$9info:eu-repo/grantAgreement/ES/ISCIII/PI19-01350
000124045 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000124045 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion
000124045 700__ $$aMontero-Calle, P.
000124045 700__ $$aIglesias-García, O.
000124045 700__ $$aMazo, M. M.
000124045 700__ $$0(orcid)0000-0003-2410-5678$$aOchoa, I.$$uUniversidad de Zaragoza
000124045 700__ $$0(orcid)0000-0002-8666-622X$$aCiriza, J.$$uUniversidad de Zaragoza
000124045 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000124045 773__ $$g632 (2023), 122589 [17 pp.]$$pInt. j. pharm.$$tInternational Journal of Pharmaceutics$$x0378-5173
000124045 8564_ $$s4008297$$uhttps://zaguan.unizar.es/record/124045/files/texto_completo.pdf$$yVersión publicada
000124045 8564_ $$s2422429$$uhttps://zaguan.unizar.es/record/124045/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000124045 909CO $$ooai:zaguan.unizar.es:124045$$particulos$$pdriver
000124045 951__ $$a2023-11-27-09:48:42
000124045 980__ $$aARTICLE