The role of metallodrugs in cellular senescence

Redrado, Marta ; Fernández-Moreira, Vanesa (Universidad de Zaragoza)

Resumen: Delivering alternative strategies to deal with cancer is a huge milestone in research. Cancer cells can give a senescence response as consequence of cellular stress or external stimuli such as the use of chemotherapies, which could end up eventually in cancer relapse. Controlling cellular senescence will surely open new cancer treatment approaches. Cancer senescence induction can be used as an added timeframe to look for alternative treatments and senolytic drugs to avoid cancer relapse destroying the senescent cells (SnCs). Within cancer senescence research, metal complexes are underdeveloped in comparison with that of organic molecules or nanoparticles. Herein, we highlight the scarce investigation performed with metal complexes in the field of senescence and how a great input on them could be a huge step towards the search of alternative cancer treatments.

Idioma: Inglés

DOI: 10.1002/ejic.202200593

Año: 2023

Publicado en: European Journal of Inorganic Chemistry 26, 4 (2023), e202200593 [10 pp.]
ISSN: 1434-1948

Factor impacto JCR: 2.2 (2023)

Categ. JCR: CHEMISTRY, INORGANIC & NUCLEAR rank: 23 / 44 = 0.523 (2023) - Q3 - T2

Factor impacto CITESCORE: 4.3 - Inorganic Chemistry (Q2)

Factor impacto SCIMAGO: 0.481 - Inorganic Chemistry (Q2)

Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/E07-20R
Financiación: info:eu-repo/grantAgreement/ES/MCIU/RED2018-102471-T
Financiación: info:eu-repo/grantAgreement/ES/MCIU/RTI2018-097836-J-I00
Financiación: info:eu-repo/grantAgreement/ES/MICINN/RYC-2018-025872-I

Tipo y forma: Article (Published version)

Área (Departamento): Área Química Inorgánica (Dpto. Química Inorgánica)