Synergistic assembly of gold and copper-iron oxide nanocatalysts to promote the simultaneous depletion of glucose and glutathione

Bonet-Aleta, J. (Universidad de Zaragoza) ; Hueso, J.L. (Universidad de Zaragoza) ; Sánchez-Uriel, L. ; Encinas-Giménez, M. (Universidad de Zaragoza) ; Irusta, S. (Universidad de Zaragoza) ; Martín-Duque, P. (Universidad de Zaragoza) ; Martínez, G. (Universidad de Zaragoza) ; Santamaría, J. (Universidad de Zaragoza)

Resumen: Glucose and glutathione (GSH) are key biomolecules for the regulation and growth of tumor cells. The use of inorganic nanocatalysts in biomedicine to target and deplete such specific molecules represents a novel and promising strategy against cancer. In this work, we present a ternary assembled nanohybrid based on Au and CuFe2O4 with the capability to simultaneously deplete glucose and GSH and generate reactive oxidative species (ROS) in a cascade process. We describe an example of a synergistic heterogeneous nanoarchitecture able to maintain the glucose oxidase-like activity of Au while preventing its deactivation in the presence of GSH. Au sites remain active due to the rapid response of the Cu–Fe co-catalyst to deplete GSH levels. This example of hybrid heterostructure represents an appealing alternative with dual-activity within the tumor microenvironment (TME) for potential anticancer therapy.

Idioma: Inglés

DOI: 10.1016/j.mtchem.2023.101404

Año: 2023

Publicado en: Materials Today Chemistry 29 (2023), 101404 [8 pp.]
ISSN: 2468-5194

Financiación: info:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCE
Financiación: info:eu-repo/grantAgreement/ES/UZ/ICTS NANBIOSIS-CIBER-BBN

Tipo y forma: Article (Published version)

Área (Departamento): Área Estomatología (Dpto. Cirugía)
Área (Departamento): Área Ingeniería Química (Dpto. Ing.Quím.Tecnol.Med.Amb.)
Área (Departamento): Área Tecnologi. Medio Ambiente (Dpto. Ing.Quím.Tecnol.Med.Amb.)