000125746 001__ 125746 000125746 005__ 20241125101128.0 000125746 0247_ $$2doi$$a10.1093/ecco-jcc/jjad001 000125746 0248_ $$2sideral$$a133275 000125746 037__ $$aART-2023-133275 000125746 041__ $$aeng 000125746 100__ $$aNoor, Nurulamin M 000125746 245__ $$aECCO topical review on biological treatment cycles in crohn’s disease 000125746 260__ $$c2023 000125746 5060_ $$aAccess copy available to the general public$$fUnrestricted 000125746 5203_ $$aThere are now a growing number of licensed biological therapies for patients with Crohn’s disease. However, there can be significant costs associated with long-term maintenance treatment, as well as some concerns about potential side-effects. As a result, there has been increasing interest in elective biological treatment discontinuation in selected patients, after a sustained period of remission. Following discontinuation, in cases of relapse, evidence to date has suggested that remission may often be regained by re-treatment with the same biological agent. Therefore, a concept has emerged in which cycles of biological therapy might be used. If this treatment strategy were to be applied in a subgroup of patients at low risk of relapse, cycling might allow a substantial number of patients to have a lower, overall therapeutic burden—ensuring decreased exposure to biological therapy but still enabling appropriate disease control.Currently, there remains uncertainty about the benefit–risk balance for using cycles of biological treatment for patients with Crohn’s disease. Accordingly, an expert panel was convened by the European Crohn’s and Colitis Organisation [ECCO] to review the published literature and agree a series of consensus practice points. The panel aimed to provide evidence-based guidance on multiple aspects of biological treatment discontinuation and cycling, including the risk of relapse after elective treatment discontinuation, predictors of probable relapse or remission, safety, patient preferences, and pharmacoeconomic aspects. Crucially, discussions about biological treatment discontinuation and cycling should be individualized, to enable shared decision-making by patients with their clinicians. 000125746 536__ $$9info:eu-repo/grantAgreement/EC/H2020/633168/EU/BIOlogical therapy CYCLEs towards tailored, needs-driven, safer and cost-effective management of Crohn’s disease/BIOCYCLE$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 633168-BIOCYCLE 000125746 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000125746 590__ $$a8.3$$b2023 000125746 592__ $$a2.705$$b2023 000125746 591__ $$aGASTROENTEROLOGY & HEPATOLOGY$$b14 / 143 = 0.098$$c2023$$dQ1$$eT1 000125746 593__ $$aMedicine (miscellaneous)$$c2023$$dQ1 000125746 593__ $$aGastroenterology$$c2023$$dQ1 000125746 594__ $$a15.5$$b2023 000125746 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000125746 700__ $$aSousa, Paula 000125746 700__ $$aBettenworth, Dominik 000125746 700__ $$0(orcid)0000-0003-0076-3529$$aGomollón, Fernando$$uUniversidad de Zaragoza 000125746 700__ $$aLobaton, Triana 000125746 700__ $$aBossuyt, Peter 000125746 700__ $$aCasanova, Maria Jose 000125746 700__ $$aDing, Nik S 000125746 700__ $$aDragoni, Gabriele 000125746 700__ $$aFurfaro, Federica 000125746 700__ $$avan Rheenen, Patrick F 000125746 700__ $$aChaparro, Maria 000125746 700__ $$aGisbert, Javier P 000125746 700__ $$aLouis, Edouard 000125746 700__ $$aPapamichael, Konstantinos 000125746 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina 000125746 773__ $$g17, 7 (2023), 1031–1045$$pJ. Crohns Colitis$$tJournal of Crohn's & colitis$$x1873-9946 000125746 8564_ $$s493608$$uhttps://zaguan.unizar.es/record/125746/files/texto_completo.pdf$$yVersión publicada 000125746 8564_ $$s2806127$$uhttps://zaguan.unizar.es/record/125746/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000125746 909CO $$ooai:zaguan.unizar.es:125746$$particulos$$pdriver 000125746 951__ $$a2024-11-22-11:58:06 000125746 980__ $$aARTICLE