000125746 001__ 125746
000125746 005__ 20241125101128.0
000125746 0247_ $$2doi$$a10.1093/ecco-jcc/jjad001
000125746 0248_ $$2sideral$$a133275
000125746 037__ $$aART-2023-133275
000125746 041__ $$aeng
000125746 100__ $$aNoor, Nurulamin M
000125746 245__ $$aECCO topical review on biological treatment cycles in crohn’s disease
000125746 260__ $$c2023
000125746 5060_ $$aAccess copy available to the general public$$fUnrestricted
000125746 5203_ $$aThere are now a growing number of licensed biological therapies for patients with Crohn’s disease. However, there can be significant costs associated with long-term maintenance treatment, as well as some concerns about potential side-effects. As a result, there has been increasing interest in elective biological treatment discontinuation in selected patients, after a sustained period of remission. Following discontinuation, in cases of relapse, evidence to date has suggested that remission may often be regained by re-treatment with the same biological agent. Therefore, a concept has emerged in which cycles of biological therapy might be used. If this treatment strategy were to be applied in a subgroup of patients at low risk of relapse, cycling might allow a substantial number of patients to have a lower, overall therapeutic burden—ensuring decreased exposure to biological therapy but still enabling appropriate disease control.Currently, there remains uncertainty about the benefit–risk balance for using cycles of biological treatment for patients with Crohn’s disease. Accordingly, an expert panel was convened by the European Crohn’s and Colitis Organisation [ECCO] to review the published literature and agree a series of consensus practice points. The panel aimed to provide evidence-based guidance on multiple aspects of biological treatment discontinuation and cycling, including the risk of relapse after elective treatment discontinuation, predictors of probable relapse or remission, safety, patient preferences, and pharmacoeconomic aspects. Crucially, discussions about biological treatment discontinuation and cycling should be individualized, to enable shared decision-making by patients with their clinicians.
000125746 536__ $$9info:eu-repo/grantAgreement/EC/H2020/633168/EU/BIOlogical therapy CYCLEs towards tailored, needs-driven, safer and cost-effective management of Crohn’s disease/BIOCYCLE$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 633168-BIOCYCLE
000125746 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000125746 590__ $$a8.3$$b2023
000125746 592__ $$a2.705$$b2023
000125746 591__ $$aGASTROENTEROLOGY & HEPATOLOGY$$b14 / 143 = 0.098$$c2023$$dQ1$$eT1
000125746 593__ $$aMedicine (miscellaneous)$$c2023$$dQ1
000125746 593__ $$aGastroenterology$$c2023$$dQ1
000125746 594__ $$a15.5$$b2023
000125746 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000125746 700__ $$aSousa, Paula
000125746 700__ $$aBettenworth, Dominik
000125746 700__ $$0(orcid)0000-0003-0076-3529$$aGomollón, Fernando$$uUniversidad de Zaragoza
000125746 700__ $$aLobaton, Triana
000125746 700__ $$aBossuyt, Peter
000125746 700__ $$aCasanova, Maria Jose
000125746 700__ $$aDing, Nik S
000125746 700__ $$aDragoni, Gabriele
000125746 700__ $$aFurfaro, Federica
000125746 700__ $$avan Rheenen, Patrick F
000125746 700__ $$aChaparro, Maria
000125746 700__ $$aGisbert, Javier P
000125746 700__ $$aLouis, Edouard
000125746 700__ $$aPapamichael, Konstantinos
000125746 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000125746 773__ $$g17, 7 (2023), 1031–1045$$pJ. Crohns Colitis$$tJournal of Crohn's & colitis$$x1873-9946
000125746 8564_ $$s493608$$uhttps://zaguan.unizar.es/record/125746/files/texto_completo.pdf$$yVersión publicada
000125746 8564_ $$s2806127$$uhttps://zaguan.unizar.es/record/125746/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000125746 909CO $$ooai:zaguan.unizar.es:125746$$particulos$$pdriver
000125746 951__ $$a2024-11-22-11:58:06
000125746 980__ $$aARTICLE