000125769 001__ 125769
000125769 005__ 20240731103326.0
000125769 0247_ $$2doi$$a10.1016/j.sbi.2023.102574
000125769 0248_ $$2sideral$$a133187
000125769 037__ $$aART-2023-133187
000125769 041__ $$aeng
000125769 100__ $$aGusach, A.
000125769 245__ $$aNew insights into GPCR coupling and dimerisation from cryo-EM structures
000125769 260__ $$c2023
000125769 5060_ $$aAccess copy available to the general public$$fUnrestricted
000125769 5203_ $$aOver the past three years (2020–2022) more structures of GPCRs have been determined than in the previous twenty years (2000–2019), primarily of GPCR complexes that are large enough for structure determination by single-particle cryo-EM. This review will present some structural highlights that have advanced our molecular understanding of promiscuous G protein coupling, how a G protein receptor kinase and β-arrestins couple to GPCRs, and GPCR dimerisation. We will also discuss advances in the use of gene fusions, nanobodies, and Fab fragments to facilitate the structure determination of GPCRs in the inactive state that, on their own, are too small for structure determination by single-particle cryo-EM.
000125769 536__ $$9info:eu-repo/grantAgreement/ES/MICINN-FEDER/PID2020-113359GA-I00
000125769 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000125769 590__ $$a6.1$$b2023
000125769 592__ $$a2.824$$b2023
000125769 591__ $$aCELL BIOLOGY$$b48 / 205 = 0.234$$c2023$$dQ1$$eT1
000125769 593__ $$aStructural Biology$$c2023$$dQ1
000125769 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b47 / 313 = 0.15$$c2023$$dQ1$$eT1
000125769 593__ $$aMolecular Biology$$c2023$$dQ1
000125769 594__ $$a12.2$$b2023
000125769 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000125769 700__ $$0(orcid)0000-0002-4254-3148$$aGarcía-Nafría, J.$$uUniversidad de Zaragoza
000125769 700__ $$aTate, C. G.
000125769 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000125769 773__ $$g80 (2023), 102574 [10 pp.]$$pCurr. opin. struck. biol.$$tCurrent Opinion in Structural Biology$$x0959-440X
000125769 8564_ $$s2605019$$uhttps://zaguan.unizar.es/record/125769/files/texto_completo.pdf$$yVersión publicada
000125769 8564_ $$s2882931$$uhttps://zaguan.unizar.es/record/125769/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000125769 909CO $$ooai:zaguan.unizar.es:125769$$particulos$$pdriver
000125769 951__ $$a2024-07-31-09:44:53
000125769 980__ $$aARTICLE