000125861 001__ 125861
000125861 005__ 20241125101203.0
000125861 0247_ $$2doi$$a10.1021/acsami.2c20566
000125861 0248_ $$2sideral$$a133188
000125861 037__ $$aART-2023-133188
000125861 041__ $$aeng
000125861 100__ $$0(orcid)0000-0001-8762-5457$$aSancho-Albero, María$$uUniversidad de Zaragoza
000125861 245__ $$aSuperfluorinated extracellular vesicles for in vivo imaging by 19f-mri
000125861 260__ $$c2023
000125861 5060_ $$aAccess copy available to the general public$$fUnrestricted
000125861 5203_ $$aExtracellular vesicles (EVs) play a crucial role in cell-to-cell communication and have great potential as efficient delivery vectors. However, a better understanding of EV in vivo behavior is hampered by the limitations of current imaging tools. In addition, chemical labels present the risk of altering the EV membrane features and, thus, in vivo behavior. 19F-MRI is a safe bioimaging technique providing selective images of exogenous probes. Here, we present the first example of fluorinated EVs containing PERFECTA, a branched molecule with 36 magnetically equivalent 19F atoms. A PERFECTA emulsion is given to the cells, and PERFECTA-containing EVs are naturally produced. PERFECTA-EVs maintain the physicochemical features, morphology, and biological fingerprint as native EVs but exhibit an intense 19F-NMR signal and excellent 19F relaxation times. In vivo 19F-MRI and tumor-targeting capabilities of stem cell-derived PERFECTA-EVs are also proved. We propose PERFECTA-EVs as promising biohybrids for imaging biodistribution and delivery of EVs throughout the body.
000125861 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/CIBER-BBN$$9info:eu-repo/grantAgreement/ES/MEC/FPU15-03419$$9info:eu-repo/grantAgreement/ES/MINECO/Consolider-Ingenio2010
000125861 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000125861 590__ $$a8.5$$b2023
000125861 592__ $$a2.058$$b2023
000125861 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b28 / 141 = 0.199$$c2023$$dQ1$$eT1
000125861 593__ $$aMaterials Science (miscellaneous)$$c2023$$dQ1
000125861 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b68 / 439 = 0.155$$c2023$$dQ1$$eT1
000125861 593__ $$aNanoscience and Nanotechnology$$c2023$$dQ1
000125861 593__ $$aMedicine (miscellaneous)$$c2023$$dQ1
000125861 594__ $$a16.0$$b2023
000125861 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000125861 700__ $$aAyaz, Nazeeha
000125861 700__ $$0(orcid)0000-0002-6873-5244$$aSebastian, Victor$$uUniversidad de Zaragoza
000125861 700__ $$aChirizzi, Cristina
000125861 700__ $$aEncinas-Gimenez, Miguel$$uUniversidad de Zaragoza
000125861 700__ $$aNeri, Giulia
000125861 700__ $$aChaabane, Linda
000125861 700__ $$0(orcid)0000-0002-2053-9842$$aLuján, Lluís$$uUniversidad de Zaragoza
000125861 700__ $$aMartin-Duque, Pilar
000125861 700__ $$aMetrangolo, Pierangelo
000125861 700__ $$0(orcid)0000-0002-8701-9745$$aSantamaría, Jesús$$uUniversidad de Zaragoza
000125861 700__ $$aBaldelli Bombelli, Francesca
000125861 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000125861 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000125861 773__ $$g15 (2023), 8974-8985$$pACS appl. mater. interfaces$$tACS applied materials & interfaces$$x1944-8244
000125861 8564_ $$s9944759$$uhttps://zaguan.unizar.es/record/125861/files/texto_completo.pdf$$yVersión publicada
000125861 8564_ $$s2782234$$uhttps://zaguan.unizar.es/record/125861/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000125861 909CO $$ooai:zaguan.unizar.es:125861$$particulos$$pdriver
000125861 951__ $$a2024-11-22-12:12:39
000125861 980__ $$aARTICLE