000126331 001__ 126331
000126331 005__ 20230602105036.0
000126331 0247_ $$2doi$$a10.1093/genetics/iyac146
000126331 0248_ $$2sideral$$a131290
000126331 037__ $$aART-2023-131290
000126331 041__ $$aeng
000126331 100__ $$aScarlett, Virginia T
000126331 245__ $$aMultiple origins, one evolutionary trajectory: gradual evolution characterizes distinct lineages of allotetraploid "Brachypodium"
000126331 260__ $$c2023
000126331 5060_ $$aAccess copy available to the general public$$fUnrestricted
000126331 5203_ $$aThe “genomic shock” hypothesis posits that unusual challenges to genome integrity such as whole genome duplication may induce chaotic genome restructuring. Decades of research on polyploid genomes have revealed that this is often, but not always the case. While some polyploids show major chromosomal rearrangements and derepression of transposable elements in the immediate aftermath of whole genome duplication, others do not. Nonetheless, all polyploids show gradual diploidization over evolutionary time. To evaluate these hypotheses, we produced a chromosome-scale reference genome for the natural allotetraploid grass Brachypodium hybridum, accession “Bhyb26.” We compared 2 independently derived accessions of B. hybridum and their deeply diverged diploid progenitor species Brachypodium stacei and Brachypodium distachyon. The 2 B. hybridum lineages provide a natural timecourse in genome evolution because one formed 1.4 million years ago, and the other formed 140 thousand years ago. The genome of the older lineage reveals signs of gradual post-whole genome duplication genome evolution including minor gene loss and genome rearrangement that are missing from the younger lineage. In neither B. hybridum lineage do we find signs of homeologous recombination or pronounced transposable element activation, though we find evidence supporting steady post-whole genome duplication transposable element activity in the older lineage. Gene loss in the older lineage was slightly biased toward 1 subgenome, but genome dominance was not observed at the transcriptomic level. We propose that relaxed selection, rather than an abrupt genomic shock, drives evolutionary novelty in B. hybridum, and that the progenitor species’ similarity in transposable element load may account for the subtlety of the observed genome dominance.
000126331 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FSE/A01-20R$$9info:eu-repo/grantAgreement/ES/MICINN/PID2019-108195GB-I00
000126331 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000126331 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000126331 700__ $$aLovell, John T
000126331 700__ $$aShao, Mingqin
000126331 700__ $$aPhillips, Jeremy
000126331 700__ $$aShu, Shengqiang
000126331 700__ $$aLusinska, Joanna
000126331 700__ $$aGoodstein, David M
000126331 700__ $$aJenkins, Jerry
000126331 700__ $$aGrimwood, Jane
000126331 700__ $$aBarry, Kerrie
000126331 700__ $$aChalhoub, Boulos
000126331 700__ $$aSchmutz, Jeremy
000126331 700__ $$aHasterok, Robert
000126331 700__ $$0(orcid)0000-0001-7793-5259$$aCatalán, Pilar$$uUniversidad de Zaragoza
000126331 700__ $$aVogel, John P
000126331 7102_ $$15011$$2063$$aUniversidad de Zaragoza$$bDpto. CC.Agrar.y Medio Natural$$cÁrea Botánica
000126331 773__ $$g223, 2 (2023), [14 pp.]$$pGenet.$$tGENETICS$$x0016-6731
000126331 8564_ $$s1853231$$uhttps://zaguan.unizar.es/record/126331/files/texto_completo.pdf$$yVersión publicada
000126331 8564_ $$s2987176$$uhttps://zaguan.unizar.es/record/126331/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000126331 909CO $$ooai:zaguan.unizar.es:126331$$particulos$$pdriver
000126331 951__ $$a2023-06-02-09:09:55
000126331 980__ $$aARTICLE