000126405 001__ 126405
000126405 005__ 20241125101134.0
000126405 0247_ $$2doi$$a10.3390/cells12091338
000126405 0248_ $$2sideral$$a133889
000126405 037__ $$aART-2023-133889
000126405 041__ $$aeng
000126405 100__ $$0(orcid)0000-0003-2293-363X$$aMendoza, Gracia
000126405 245__ $$aThe E1a adenoviral gene upregulates the yamanaka factors to induce partial cellular reprogramming
000126405 260__ $$c2023
000126405 5060_ $$aAccess copy available to the general public$$fUnrestricted
000126405 5203_ $$aThe induction of pluripotency by enforced expression of different sets of genes in somatic cells has been achieved with reprogramming technologies first described by Yamanaka’s group. Methodologies for generating induced pluripotent stem cells are as varied as the combinations of genes used. It has previously been reported that the adenoviral E1a gene can induce the expression of two of the Yamanaka factors (c-Myc and Oct-4) and epigenetic changes. Here, we demonstrate that the E1a-12S over-expression is sufficient to induce pluripotent-like characteristics closely to epiblast stem cells in mouse embryonic fibroblasts through the activation of the pluripotency gene regulatory network. These findings provide not only empirical evidence that the expression of one single factor is sufficient for partial reprogramming but also a potential mechanistic explanation for how viral infection could lead to neoplasia if they are surrounded by the appropriate environment or the right medium, as happens with the tumorogenic niche.
000126405 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B054-12$$9info:eu-repo/grantAgreement/ES/ISCIII DTS21-00130$$9info:eu-repo/grantAgreement/ES/ISCIII/PI19-01007
000126405 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000126405 590__ $$a5.1$$b2023
000126405 592__ $$a1.547$$b2023
000126405 591__ $$aCELL BIOLOGY$$b63 / 205 = 0.307$$c2023$$dQ2$$eT1
000126405 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2023$$dQ1
000126405 594__ $$a9.9$$b2023
000126405 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000126405 700__ $$0(orcid)0000-0002-5630-6645$$aGonzález-Pastor, Rebeca
000126405 700__ $$aSánchez, Juan Miguel
000126405 700__ $$aArce-Cerezo, Altamira
000126405 700__ $$aQuintanilla, Miguel
000126405 700__ $$aMoreno-Bueno, Gema
000126405 700__ $$aPujol, Anna
000126405 700__ $$aBelmar-López, Carolina
000126405 700__ $$ade Martino, Alba
000126405 700__ $$aRiu, Efrén
000126405 700__ $$aRodriguez, Tristan A.
000126405 700__ $$0(orcid)0000-0003-4160-9720$$aMartin-Duque, Pilar$$uUniversidad de Zaragoza
000126405 7102_ $$11013$$2275$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Estomatología
000126405 773__ $$g12, 9 (2023), 1338 [17 pp.]$$pCells$$tCells$$x2073-4409
000126405 8564_ $$s3080341$$uhttps://zaguan.unizar.es/record/126405/files/texto_completo.pdf$$yVersión publicada
000126405 8564_ $$s2654036$$uhttps://zaguan.unizar.es/record/126405/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000126405 909CO $$ooai:zaguan.unizar.es:126405$$particulos$$pdriver
000126405 951__ $$a2024-11-22-11:59:57
000126405 980__ $$aARTICLE