000126545 001__ 126545
000126545 005__ 20241125101145.0
000126545 0247_ $$2doi$$a10.1021/acs.biomac.3c00257
000126545 0248_ $$2sideral$$a134047
000126545 037__ $$aART-2023-134047
000126545 041__ $$aeng
000126545 100__ $$0(orcid)0000-0003-1958-4432$$aAlamán-Díez, P.$$uUniversidad de Zaragoza
000126545 245__ $$aCollagen-laponite nanoclay hydrogels for tumor spheroid growth
000126545 260__ $$c2023
000126545 5060_ $$aAccess copy available to the general public$$fUnrestricted
000126545 5203_ $$aThe extracellular matrix (ECM) plays an important regulatory role in the development and progression of tumoral tissue. Its functions and properties are crucial in determining tumor cell behavior such as invasion, migration, and malignancy development. Our study explores the role of collagen type I in cancer development and spread using engineered tumor models like multicellular spheroids grown in collagen-based hydrogels to simulate early tumor formation. We employ microfluidic techniques to test the hypothesis that (i) adding Laponite nanoclay to collagen hydrogels modifies mechanical and rheological properties and (ii) changing the stiffness of the collagen microenvironment affects tumor spheroid growth. Our findings support our theories and suggest the use of ECM components and engineered tumor models in cancer research, offering a biocompatible and biomimetic method to tailor the mechanical properties of conventional collagen hydrogels.
000126545 536__ $$9info:eu-repo/grantAgreement/ES/DGA/2018-22$$9info:eu-repo/grantAgreement/EC/H2020/101018587/EU/Individual and Collective Migration of the Immune Cellular System/ICoMICS$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 101018587-ICoMICS$$9info:eu-repo/grantAgreement/EC/H2020/826494/EU/PRedictive In-silico Multiscale Analytics to support cancer personalized diaGnosis and prognosis, Empowered by imaging biomarkers/PRIMAGE$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 826494-PRIMAGE$$9info:eu-repo/grantAgreement/ES/MICINN/RYC2021-033490-I$$9info:eu-repo/grantAgreement/ES/MINECO-AEI-FEDER/PID2021-122409OB-C21$$9info:eu-repo/grantAgreement/ES/MINECO/PID2020-113819RB-I00$$9info:eu-repo/grantAgreement/ES/MINECO/PID2020-125762NB-I00
000126545 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000126545 590__ $$a5.5$$b2023
000126545 592__ $$a1.232$$b2023
000126545 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b58 / 313 = 0.185$$c2023$$dQ1$$eT1
000126545 593__ $$aBioengineering$$c2023$$dQ1
000126545 591__ $$aPOLYMER SCIENCE$$b10 / 95 = 0.105$$c2023$$dQ1$$eT1
000126545 593__ $$aPolymers and Plastics$$c2023$$dQ1
000126545 591__ $$aCHEMISTRY, ORGANIC$$b3 / 58 = 0.052$$c2023$$dQ1$$eT1
000126545 593__ $$aMaterials Chemistry$$c2023$$dQ1
000126545 593__ $$aBiomaterials$$c2023$$dQ1
000126545 594__ $$a10.6$$b2023
000126545 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000126545 700__ $$0(orcid)0000-0002-3784-1140$$aBorau, C.$$uUniversidad de Zaragoza
000126545 700__ $$0(orcid)0000-0003-2612-9235$$aGuerrero, P. E.$$uUniversidad de Zaragoza
000126545 700__ $$0(orcid)0000-0003-2212-447X$$aAmaveda, H.$$uUniversidad de Zaragoza
000126545 700__ $$0(orcid)0000-0003-4747-7327$$aMora, M.$$uUniversidad de Zaragoza
000126545 700__ $$0(orcid)0000-0002-0136-5138$$aFraile, J. M.
000126545 700__ $$0(orcid)0000-0001-7062-9099$$aGarcía-Gareta, E.$$uUniversidad de Zaragoza
000126545 700__ $$0(orcid)0000-0002-9864-7683$$aGarcía-Aznar, J. M.$$uUniversidad de Zaragoza
000126545 700__ $$0(orcid)0000-0002-2901-4188$$aPérez, M. Á.$$uUniversidad de Zaragoza
000126545 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000126545 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000126545 7102_ $$15001$$2065$$aUniversidad de Zaragoza$$bDpto. Ciencia Tecnol.Mater.Fl.$$cÁrea Cienc.Mater. Ingen.Metal.
000126545 773__ $$g24, 6 (2023), 2879-2891$$pBiomacromolecules$$tBIOMACROMOLECULES$$x1525-7797
000126545 8564_ $$s12048888$$uhttps://zaguan.unizar.es/record/126545/files/texto_completo.pdf$$yVersión publicada
000126545 8564_ $$s3232101$$uhttps://zaguan.unizar.es/record/126545/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000126545 909CO $$ooai:zaguan.unizar.es:126545$$particulos$$pdriver
000126545 951__ $$a2024-11-22-12:04:23
000126545 980__ $$aARTICLE