000126591 001__ 126591
000126591 005__ 20241125101138.0
000126591 0247_ $$2doi$$a10.3390/ijms24087459
000126591 0248_ $$2sideral$$a133876
000126591 037__ $$aART-2023-133876
000126591 041__ $$aeng
000126591 100__ $$aPariente, Ana
000126591 245__ $$aIdentification of 7-Ketocholesterol-Modulated Pathways and Sterculic Acid Protective Effect in Retinal Pigmented Epithelium Cells by Using Genome-Wide Transcriptomic Analysis
000126591 260__ $$c2023
000126591 5060_ $$aAccess copy available to the general public$$fUnrestricted
000126591 5203_ $$aAge-related macular degeneration (AMD) is the leading cause of blindness in developed countries. AMD is characterized by the formation of lipidic deposits between the retinal pigment epithelium (RPE) and the choroid called drusen. 7-Ketocholesterol (7KCh), an oxidized-cholesterol derivative, is closely related to AMD as it is one of the main molecules accumulated in drusen. 7KCh induces inflammatory and cytotoxic responses in different cell types, and a better knowledge of the signaling pathways involved in its response would provide a new perspective on the molecular mechanisms that lead to the development of AMD. Furthermore, currently used therapies for AMD are not efficient enough. Sterculic acid (SA) attenuates the 7KCh response in RPE cells and is presented as an alternative to improve these therapies. By using genome-wide transcriptomic analysis in monkey RPE cells, we have provided new insight into 7KCh-induced signaling in RPE cells, as well as the protective capacity of SA. 7KCh modulates the expression of several genes associated with lipid metabolism, endoplasmic reticulum stress, inflammation and cell death and induces a complex response in RPE cells. The addition of SA successfully attenuates the deleterious effect of 7KCh and highlights its potential for the treatment of AMD.
000126591 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/CPII20-00029$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI19/01805
000126591 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000126591 590__ $$a4.9$$b2023
000126591 592__ $$a1.179$$b2023
000126591 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b66 / 313 = 0.211$$c2023$$dQ1$$eT1
000126591 593__ $$aMedicine (miscellaneous)$$c2023$$dQ1
000126591 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b68 / 231 = 0.294$$c2023$$dQ2$$eT1
000126591 593__ $$aPhysical and Theoretical Chemistry$$c2023$$dQ1
000126591 593__ $$aComputer Science Applications$$c2023$$dQ1
000126591 593__ $$aInorganic Chemistry$$c2023$$dQ1
000126591 593__ $$aSpectroscopy$$c2023$$dQ1
000126591 593__ $$aOrganic Chemistry$$c2023$$dQ1
000126591 593__ $$aMolecular Biology$$c2023$$dQ2
000126591 593__ $$aCatalysis$$c2023$$dQ2
000126591 594__ $$a8.1$$b2023
000126591 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000126591 700__ $$aPérez-Sala, Álvaro
000126591 700__ $$aOchoa, Rodrigo
000126591 700__ $$aBobadilla, Miriam
000126591 700__ $$aVillanueva-Martínez, Ángela
000126591 700__ $$aPeláez, Rafael
000126591 700__ $$aLarráyoz, Ignacio M.
000126591 773__ $$g24, 8 (2023), 7459 [22 pp.]$$pInt. j. mol. sci.$$tInternational Journal of Molecular Sciences$$x1661-6596
000126591 8564_ $$s4327189$$uhttps://zaguan.unizar.es/record/126591/files/texto_completo.pdf$$yVersión publicada
000126591 8564_ $$s2781713$$uhttps://zaguan.unizar.es/record/126591/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000126591 909CO $$ooai:zaguan.unizar.es:126591$$particulos$$pdriver
000126591 951__ $$a2024-11-22-12:01:45
000126591 980__ $$aARTICLE