000126855 001__ 126855
000126855 005__ 20241125101154.0
000126855 0247_ $$2doi$$a10.1038/s41598-023-33487-3
000126855 0248_ $$2sideral$$a134206
000126855 037__ $$aART-2023-134206
000126855 041__ $$aeng
000126855 100__ $$aSarreshtehdari, Amirhossein
000126855 245__ $$aPreliminary evaluation of the safety and efficacy of glucose solution infusion through the hepatic artery on irreversible electroporation focusing
000126855 260__ $$c2023
000126855 5060_ $$aAccess copy available to the general public$$fUnrestricted
000126855 5203_ $$aDue to electrical features of the tissue, such as impedance, which have a significant impact on irreversible electroporation (IRE) function, the administration of glucose solution 5% (GS5%) through the hepatic artery would focus IRE on scattered liver tumors. By creating a differential impedance between healthy and tumor tissue. This study aimed to determine the effects of the GS5% protocol on healthy liver tissue and its safety. 21 male Athymic nude rats Hsd: RH-Foxn1mu were used in the study. Animals were split into two groups. In group 1, a continuous infusion through the gastroduodenal artery of GS5% was performed to measure the impedance with a dose of 0.008 mL/g for 16 min. In group 2, the animals were divided into two subgroups for infusions of GS5%. Group 2.1, at 0.008 mL/g for 16 min. Group 2.2 at 0.03 mL/g for 4 min. Blood samples were collected after anesthesia has been induced. The second sample, after catheterization of the artery, and the third after the GS5% infusion. All the animals were sacrificed to collect histological samples. The survival rate during the experiment was 100%. A considerable impact on the impedance of the tissue was noticed, on average up to 4.31 times more than the baseline, and no side effects were observed after GS5% infusion. In conclusion, impedance alteration by Glucose solution infusion may focus IRE on tumor tissue and decrease IRE’s effects on healthy tissue.
000126855 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI17-0048$$9info:eu-repo/grantAgreement/ES/ISCIII/PI21-00440$$9info:eu-repo/grantAgreement/ES/MINECO/RTI2018-094357-B-C21$$9info:eu-repo/grantAgreement/ES/MINECO/RTI2018-094357-B-C22
000126855 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000126855 590__ $$a3.8$$b2023
000126855 592__ $$a0.9$$b2023
000126855 591__ $$aMULTIDISCIPLINARY SCIENCES$$b25 / 134 = 0.187$$c2023$$dQ1$$eT1
000126855 593__ $$aMultidisciplinary$$c2023$$dQ1
000126855 594__ $$a7.5$$b2023
000126855 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000126855 700__ $$aBurdio, Fernando
000126855 700__ $$0(orcid)0000-0003-2848-170X$$aLópez-Alonso, Borja$$uUniversidad de Zaragoza
000126855 700__ $$0(orcid)0000-0002-1284-9007$$aLucía, Óscar$$uUniversidad de Zaragoza
000126855 700__ $$0(orcid)0000-0002-9655-5531$$aBurdio, José Miguel$$uUniversidad de Zaragoza
000126855 700__ $$aVillamonte, María
000126855 700__ $$aAndaluz, A.
000126855 700__ $$aGarcía-Arnas, F.
000126855 700__ $$aBerjano, E.
000126855 700__ $$aMoll, Xavier
000126855 7102_ $$15008$$2785$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Tecnología Electrónica
000126855 773__ $$g13 (2023), 7120 [9 pp.]$$pSci. rep. (Nat. Publ. Group)$$tScientific reports (Nature Publishing Group)$$x2045-2322
000126855 8564_ $$s1477033$$uhttps://zaguan.unizar.es/record/126855/files/texto_completo.pdf$$yVersión publicada
000126855 8564_ $$s2419756$$uhttps://zaguan.unizar.es/record/126855/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000126855 909CO $$ooai:zaguan.unizar.es:126855$$particulos$$pdriver
000126855 951__ $$a2024-11-22-12:08:32
000126855 980__ $$aARTICLE