Persistence of Anti-S1 IgG against SARS-CoV-2 eight months after the Booster dose of Vaccine in naive and previously infected healthcare workers

Algarate, Sonia (Universidad de Zaragoza) ; Serrano, Laura ; Bueno, Jessica (Universidad de Zaragoza) ; Herrero-Cortina, Beatriz ; Alvarado, Elena ; González-Barriga, María T. ; Ducons, María ; Montero-Marco, Jesica ; Arnal, Sara ; Acha, Beatriz (Universidad de Zaragoza) ; Riesgo, María ; Taboada, Ana ; Sanz-Burillo, Pilar ; Yuste, Cristina ; Benito, Rafael (Universidad de Zaragoza) ; RIPOVAC Study Group

Resumen: Our aim was to evaluate the immune response of healthcare workers included in the RIPOVAC study, after receiving a booster dose (third dose), in terms of intensity and persistence of induced antibodies. In the second phase of the RIPOVAC study, between December 2021 and January 2022, eight months after the second dose, 389 voluntary, immunocompetent, non-pregnant healthcare workers received a booster dose of SARS-CoV-2 vaccine, and a serum sample was obtained. Two groups of patients were established: with and without previous SARS-CoV-2 infection. In order to quantify anti-S1 IgG (AU/mL) we used CMIA (Abbott). All of the health workers were anti-S IgG positive 8 months after receiving the booster dose of the vaccine, with a mean of 17,040 AU/mL. In 53 patients without previous infection, antibody levels increased by a mean of 10,762 AU/mL. This figure is seven times higher than the one produced after the second dose (1506 AU/mL). The booster dose produces a robust elevation of the antibody level, which persists at 8 months, with levels significantly higher than those reached after the second dose, which allow one to predict a persistence of more than one year. The study demonstrates the efficacy of the booster dose of anti-SARS-CoV-2 vaccines.

Idioma: Inglés

DOI: 10.3390/ijms241310713

Año: 2023

Publicado en: International Journal of Molecular Sciences 24, 13 (2023), 10713 [7 pp.]
ISSN: 1661-6596

Factor impacto JCR: 4.9 (2023)

Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 66 / 313 = 0.211 (2023) - Q1 - T1
Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 68 / 231 = 0.294 (2023) - Q2 - T1

Factor impacto CITESCORE: 8.1 - Spectroscopy (Q1) - Computer Science Applications (Q1) - Physical and Theoretical Chemistry (Q1) - Inorganic Chemistry (Q1) - Organic Chemistry (Q1) - Molecular Biology (Q2) - Catalysis (Q2)

Factor impacto SCIMAGO: 1.179 - Medicine (miscellaneous) (Q1) - Physical and Theoretical Chemistry (Q1) - Computer Science Applications (Q1) - Inorganic Chemistry (Q1) - Spectroscopy (Q1) - Organic Chemistry (Q1) - Molecular Biology (Q2) - Catalysis (Q2)

Tipo y forma: Article (Published version)

Área (Departamento): Área Enfermería (Dpto. Fisiatría y Enfermería)
Área (Departamento): Área Microbiología (Dpto. Microb.Ped.Radio.Sal.Pú.)