Beyond tuberculosis: Diversity and implications of non-tuberculous mycobacteria at the wildlife–livestock interface

Varela-Castro, L. ; Barral, M. ; Arnal, M. C. (Universidad de Zaragoza) ; Fernández de Luco, D. (Universidad de Zaragoza) ; Gortázar, C. ; Garrido, J. M. ; Sevilla, I. A.

Resumen: Non-tuberculous mycobacteria (NTM) circulate between the environment, animals and humans entailing a double concern: their ability to interfere with tuberculosis diagnosis and their potential to cause infections in their hosts. However, published records on NTM infections in animals are still scarce. The aims of the present study were to describe the diversity of NTM circulating among wild and domestic species from Spain and to analyze their implications as potential pathogenic microorganisms or as sources of interferences in the diagnosis of bovine tuberculosis. Overall, 293 NTM isolates of 277 animals were obtained from tissue samples collected between 2012 and 2019, and analyzed through a multigene approach for mycobacteria identification. Thirty-one species were identified, being Mycobacterium avium subsp. avium (Maa) and M. avium subsp. hominissuis (Mah), but also M. bouchedurhonense, M. nonchromogenicum and M. lentiflavum, the most abundant ones. Maa and M. lentiflavum were isolated in several animals showing tuberculosis-like lesions. Maa, Mah and M. nonchromogenicum were recovered from many cattle that had reacted to the tuberculin skin test. Other NTM were also associated to these phenomena. These four mycobacterial species were geographically associated between wild boar and other hosts. The findings of the present study suggest that a high diversity of NTM circulates among wildlife and livestock. Wild boar and M. avium seem to play a relevant role in this epidemiological scenario.

Idioma: Inglés

DOI: 10.1111/tbed.14649

Año: 2022

Publicado en: Transboundary and Emerging Diseases 69, 5 (2022), e2978-e2993
ISSN: 1865-1674

Factor impacto JCR: 4.3 (2022)

Categ. JCR: VETERINARY SCIENCES rank: 7 / 144 = 0.049 (2022) - Q1 - T1
Categ. JCR: INFECTIOUS DISEASES rank: 42 / 96 = 0.438 (2022) - Q2 - T2

Factor impacto CITESCORE: 7.4 - Medicine (Q1) - Immunology and Microbiology (Q2) - Veterinary (Q1)

Factor impacto SCIMAGO: 0.99 - Medicine (miscellaneous) (Q1) - Veterinary (miscellaneous) (Q1) - Immunology and Microbiology (miscellaneous) (Q2)

Financiación: info:eu-repo/grantAgreement/ES/AEI/PID2019-105155RB-C33
Financiación: info:eu-repo/grantAgreement/ES/INIA/CPD-2016-0006
Financiación: info:eu-repo/grantAgreement/ES/Interreg POCTEFA 357-19-INNOTUB AND VEPIFAUS

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Sanidad Animal (Dpto. Patología Animal)