Pathophysiological implications of interstitial Cajal-like cells (ICC-like) in uterus: A comparative study with gastrointestinal ICCs

López-Pingarrón, Laura (Universidad de Zaragoza) ; Almeida, Henrique ; Pereboom-Maicas, Matilde Desirée (Universidad de Zaragoza) ; García García, José Joaquín (Universidad de Zaragoza)

Resumen: The main function of interstitial cells of Cajal (ICCs) is to regulate gastrointestinal peristalsis by acting as a “pacemaker” cell by generating spontaneous slow electrical waves. In 2005, electron microscopy revealed a cell type similar to ICCs (ICC-like) outside the gastrointestinal tract, with contractile activity and c-Kit+ immunohistochemistry shared with ICCs. Among the locations where ICC-like cells have been observed, it is in the uterus where they have a significant functional and pathophysiological role. These cells are involved in obstetric phenomena of contractile action, such
as ascending sperm transport, embryo implantation, pregnancy, delivery, and the expulsion of menstrual debris. Within the pathophysiology related to these cells, we find obstetric alterations such as recurrent miscarriages, premature deliveries, abolition of uterine contractions, and failures of
embryo implantation, in addition to other common conditions in the fertile age, such as endometriosis and leiomyoma.

Idioma: Inglés

DOI: 10.3390/cimb45090476

Año: 2023

Publicado en: CURRENT ISSUES IN MOLECULAR BIOLOGY 45 (2023), 7557–7571
ISSN: 1467-3037

Factor impacto JCR: 2.8 (2023)

Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 184 / 313 = 0.588 (2023) - Q3 - T2

Factor impacto CITESCORE: 2.9 - Microbiology (medical) (Q3) - Microbiology (Q3) - Molecular Biology (Q4)

Factor impacto SCIMAGO: 0.675 - Medicine (miscellaneous) (Q2) - Microbiology (Q2) - Microbiology (medical) (Q2) - Molecular Biology (Q3)

Financiación: info:eu-repo/grantAgreement/ES/DGA/B56-23D

Tipo y forma: Article (Published version)

Área (Departamento): Área Fisiología (Dpto. Farmac.Fisiol.y Med.L.F.)